Details About Generic Salt ::  Cyproterone 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

8F. ANDROGENS AND ANTI-ANDROGENS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
CYPROTERONE
PROGESTOGEN | ANTI-ANDROGEN
PK: A: Rapid & complete (PO) M: Hepatic E: Urine (35%, as metabolites), feces (60%)

Indications & Dose: PROSTATIC CARCINOMA Palliative therapy PO Adult Male: 200-300mg/day in 2-3 divided doses following orchiectomy, reduce dose to 100-200mg/day | Palliative therapy IM Adult 300mg (3mL) once weekly, reduce dose in orchiectomized patients to 300mg q2wk

Contra: Hypersensitivity, active liver disease/hepatic dysfunction, renal impairment, malignant/wasting diseases, severe diabetes with vascular changes, sickle-cell anemia, history of thromboembolic disorders

Precautions: Depression, CVD, DM, patients with familial defects of lipoprotein metabolism, prostate cancer

ADR: Serious: Hypotension, MI, HF, stroke, hemorrhage, thrombosis, osteoporosis, hepatitis, jaundice & hepatic failure, infertility, atrophy of seminiferous tubules, abnormal spermatozoa, reduces volume of ejaculate, Others: gynecomastia, reduces libido, enlargement of mammary glands, galactorrhoea, fatigue & weakness, weight changes, dry skin, depression, dizziness, encephalopathy, rashes/hypersensitivity

DDI: Serious Alcohol reduces drug efficacy

Diet: With food

Monitor: LFTs, signs/symptoms of hepatotoxicity, adrenal function

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