Details About Generic Salt ::  Rivastigmine 

Main Medicine Class:: Nervous System   Sub Medicine Class ::  Drugs for Neurodegenerative Disorders

1F. DRUGS FOR NEURODEGENERATIVE DISORDERS in 1. NERVOUS SYSTEM
RIVASTIGMINE
CHOLINESTERASE INHIBITOR | ANTI-ALZHEIMER
PK: A: Rapid (PO) D: 1.8-2.7 L/kg (Vd) M: Brain E: Urine , feces

Indications & Dose: DEMENTIA IN ALZHEIMER’S DISEASE Mild-to-moderate PO Adult Initially 1.5mg BID, increase dose by 1.5mg BID based on response & tolerance with at least of 2 wk gap, max 6mg BID | Mild-to-moderate TD Adult Initially patch containing 4.6mg of rivastigmine is used OD, then increased to 9.5mg/day after 4 wk if tolerated | IDIOPATHIC PARKINSON’S DISEASE PO Adult Initially 1.5mg BID, increase dose by 1.5mg BID based on response & tolerance with at least of 2 wk gap, max 6mg BID | TD Adult Initially patch containing 4.6mg of rivastigmine is used OD, then increased to 9.5mg/day after 4 wk if tolerated

Contra: Hypersensitivity

Precautions: PUD, COPD/asthma, cardiac conduction abnormalities, seizures, urinary tract obstruction

ADR: Serious: vagotonic effects, parkinsonism symptoms worsening, syncope, HTN, tremor, SJS, Others: rhinitis, diaphoresis, aggressiveness, malaise, dyspepsia, UTI, dyspepsia, constipation, dizziness, anorexia/weight loss, nausea, vomiting

DDI: Serious Levodopa causes worsening of Parkinson’s disease, Cholinergic agonists enhances adverse/toxic effect, β-blockers/CCBs enhances bradycardic effect, Tobacco increases drug clearance, Amiodarone results in bradycardia

Diet: With food

Monitor: Cognitive function at periodic intervals, symptoms of GI intolerance, weight

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