Diagnosis Systemic Sclerosis — Scleroderma (systemic sclerosis [SSc]) is a chronic disease of unknown cause characterized by diffuse fibrosis of skin and visceral organs and vascular abnormalities History Raynaud phenomenon is frequently the initial complaint. Skin thickening, “puffy hands,” and gastroesophageal reflux disease (GERD) are often noted early in the...
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