Article Contents ::
Details About Generic Salt :: Tizanidine
Main Medicine Class:: Musculoskeletal Disorders , Pain Sub Medicine Class :: Skeletal Muscle Relaxants
| 12A. SKELETAL MUSCLE RELAXANTS in 12. MUSCULOSKELETAL DISORDERS & PAIN |
| TIZANIDINE |
| A-ADRENERGIC AGONIST | SKELETAL MUSCLE RELAXANT |
| PK: A: Well absorbed M: Hepatic E: Urine |
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Indications & Dose: SPASTICITY PO Adult Initially 4mg, may increase 2-4mg q6-8h, max 3doses/day |
| Contra: Hypersensitivity, ciprofloxacin/fluvoxamine, other CYP1A2 inhibitors
Precautions: hypotension, renal/hepatic impairment, CNS depressants, elderly, abrupt withdrawal ADR: Serious: hypotension, UTI, pharyngitis, rhinitis, liver enzymes increased, myasthenia gravis, Others: nervousness, speech disorder, visual hallucinations, skin ulcer, rash, dyskinesia, paresthesia, blurred vision, flu-like syndrome, constipation, vomiting, abdominal pain, dyspepsia, diaphoresis, infect DDI: Serious Lisinopril causes severe hypotension, Amiodarone/Aciclovir/Cimetidine/Famotidine/Hormonal Contraceptives/Mexiletine/Propafenone/Ticlopidine/Verapamil increases adverse effects, Fluvoxamine/Ciprofloxacin increases hypotensive & sedative effects of drug, Diuretics leads to bradycardia & hypotension Diet: With/without food Monitor: Vital signs, LFT |