Article Contents ::
Details About Generic Salt :: Phenoxybenzamine
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 4A. DRUGS FOR CARDIAC FAILURE & SHOCK in 4. CARDIOVASCULAR SYSTEM |
| PHENOXYBENZAMINE |
| A-ADRENERGIC BLOCKER | ANTI-HYPERTENSIVE IN PHEOCHROMOCYTOMA |
| also comes under 4D. Anti-Hypertensives in 4. Cardiovascular System, , 10C. Drugs For Prostate Disorders in 10. Genito-Urinary System |
| PK: A: Incomplete & variable M: Hepatic E: Urine; bile |
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Indications & Dose: HYPERTENSION IN PHEOCHROMOCYTOMA PO Adult Initially 10mg OD/BID, increased gradually according to the response to usual dose 1-2mg/kg/day in 2 divided doses Child 1 month–18 yr: 0.5–1mg/kg BID adjusted according to response | IV Adult Inf: 1mg/kg/day over 2h Child Inf: 1 month–18 yr: 0.5–1 mg/kg/day may be adjusted according to response up to 2mg/kg/day200 mL of 0.9% Nacl | SEVERE SHOCK IV Adult Inf: 1mg/kg/day over 2hin 200-500mL 0.9% Nacl | URINARY RETENTION DUE TO NEUROGENIC BLADDER PO Adult 10mg BID |
| Contra: Porphyria
Precautions: HF, IHD, cerebrovascular disease, renal impairment, stop drug if severe hypotension occurs ADR: Serious: Orthostatic hypotension, convulsions, inhibition of ejaculation, idiosyncratic profound hypotension, Others: sweating, dizziness, reflex tachycardia, nasal congestion, miosis |