Article Contents ::
Details About Generic Salt :: Tibolone
Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System Sub Medicine Class :: Progestins and Anti Progestins
| 8G. PROGESTINS AND ANTI-PROGESTINS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM |
| TIBOLONE |
| ESTROGEN & PROGESTOGEN COMBINATION |
| PK: A: Rapid & extensive E: Bile, feces & urine |
|
Indications & Dose: HOT FLUSH & SWEATING Symptomatic therapy PO Adult 2.5mg OD continue at least 3 months to achieve optimal response | PREVENTION OF POSTMENOPAUSAL OSTEOPOROSIS PO Adult 2.5mg OD continue at least 3 months to achieve optimal response |
| Contra: CVD, cerebrovascular disorders, history of hormone dependent tumors, severe liver disorders, porphyria, untreated endometrial hyperplasia, undiagnosed vaginal bleeding, premenopausal women
Precautions: Endometriosis, uterine fibroids, renal dysfunction, cardiac dysfunction, DM, epilepsy, migraine, history of dyslipidemia ADR: Serious: myalgia, arthralgia, leucorrhea, candidiasis, vaginitis, irregular vaginal bleeding, breast cancer, liver dysfunction, visual disturbances, Others: weight gain, dizziness, skin reactions, headache, GI disturbances, hypertrichosis, depression DDI: Serious Antidiabetics impairs glucose tolerance, Warfarin increases INR |