Details About Generic Salt ::  Amikacin

Main Medicine Class:: Antibiotic,aminoglycoside   

(am-ih-KAE-sin SULL-fate)

Amikin

Class: Antibiotic/aminoglycoside

Drugs Class ::

 Action Inhibits production of bacterial protein, causing bacterial cell death.

Indications for Drugs ::

 Indications Treatment of infections caused by susceptible strains of microorganisms, especially gram-negative bacteria.

Drug Dose ::

 Route/Dosage

ADULTS, CHILDREN & INFANTS: IV/IM 15 mg/kg (ideal body weight)/day in 2 or 3 divided doses. Treatment in heavier patients should not exceed 1.5 g/day. UNCOMPLICATED UTIS: IV/IM 250 mg bid. NEONATES: IV/IM Loading dose of 10 mg/kg is recommended followed by 7.5 mg/kg q 12 hr. Lower doses may be needed in first 2 wk of life.

Contraindication ::

 Contraindications Generally not indicated for long-term therapy because of ototoxicity and nephrotoxicity.

Drug Precautions ::

 Precautions

Pregnancy: Category D. Lactation: Undetermined. Children: Cautious use is necessary in premature infants and neonates because of renal immaturity. Nephrotoxicity/ototoxicity: If patient has signs and symptoms of nephrotoxicity or ototoxicity, discontinuation or dosage adjustment is needed. Renal impairment: Dosage adjustment is needed in patients with this condition.

Drug Side Effects ::

 Adverse Reactions

EENT: Hearing loss; deafness; loss of balance. GU: Oliguria; proteinuria; increased serum creatinine; urinary casts; red and white blood cells in urine; azotemia. OTHER: Decreased serum magnesium.

Drug Mode of Action ::  

 Action Inhibits production of bacterial protein, causing bacterial cell death.

Drug Interactions ::

 Interactions

Drugs with nephrotoxic potential (eg, cephalosporins, enflurane, methoxyflurane, vancomycin): May increase risk of nephrotoxicity. Loop diuretics (eg, furosemide): May increase risk of auditory toxicity. Neuromuscular blocking agents (eg, tubocurarine): Amikacin may enhance effects of these agents. INCOMPATIBILITIES: Do not mix with betalactam antibiotics (eg, carbenicillin, ticarcillin).

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note hypersensitivity to aminoglycosides.
• Assess renal and auditory function before administration and monitor periodically during therapy to detect nephrotoxicity or ototoxicity.
• Send blood for culture and sensitivity before beginning therapy.
• Monitor patient for signs and symptoms of yeast infections during therapy.
• Monitor I&O during therapy; maintain good hydration.
• Assess patient for signs of infection to determine effectiveness of therapy.
• Notify physician and stop infusion if patient has signs of oliguria or shows signs of renal failure (eg, edema, shortness of breath, pruritus), ototoxicity or anaphylactic reaction.

Drug Storage/Management ::

 Administration/Storage

• Dilute with normal saline or D5W according to instructions.
• Administer by IV or IM route only.
• Use volumetric IV pump to regulate delivery.
• Avoid overrapid administration, which may result in respiratory depression and arrest; give over 30 to 60 min.
• Do not mix with or administer within 1 hr of other IV medications because of potential for incompatibility or inactivation.
• Discard diluted solution after 24 hr.
• When giving by IM route, use deep, slow injection; rotate sites to prevent tissue irritation or breakdown.

Drug Notes ::

 Patient/Family Education

• Encourage patient to increase fluid intake to 2000 to 3000 ml/day, unless contraindicated.
• Warn patient that diarrhea and abdominal bloating are common side effects of antibiotics.
• Inform patient that improvement should be seen in 3 to 5 days.
• Instruct patient to report the following signs to physician: Hypersensitivity, tinnitus, vertigo, hearing loss.
• Teach patient to look for signs of renal failure and to notify physician immediately if these signs occur.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.