Details About Generic Salt ::  Aspirin

Main Medicine Class:: Analgesic,salicylate   

(ASS-pihr-in)

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Class: Analgesic/salicylate

Drugs Class ::

 Action Inhibits prostaglandin synthesis, resulting in analgesia, anti-inflammatory activity and platelet aggregation inhibition; reduces fever by acting on the brain’s heat-regulating center to promote vasodilation and sweating.

Indications for Drugs ::

 Indications Treatment of mild-to-moderate pain; fever; various inflammatory conditions; reduction of risk of death or MI in patients with previous infarction or unstable angina pectoris or recurrent transient ischemia attacks or stroke in men who have had transient brain ischemia caused by platelet emboli. Unlabeled use(s): Prevention of cataract formation; prevention of toxemia of pregnancy; improvement of inadequate uteroplacental blood flow in pregnancy.

Drug Dose ::

 Route/Dosage

Analgesic/Antipyretic

ADULTS: PO 325 to 650 mg q 4 hr prn; 500 mg q 3 hr prn; 1000 mg q 6 hr prn. CHILDREN (2 TO 12 YR): PO 10 to 15 mg/kg/dose q 4 hr prn (up to 80 mg/kg/day).

Arthritis and Other Rheumatic Conditions

ADULTS: PO 3.2 to 6 g/day in divided doses.

Juvenile Rheumatoid Arthritis

CHILDREN: PO 60 to 110 mg/kg/day in divided doses q 6 to 8 hr.

Acute Rheumatic Fever

ADULTS: PO 5 to 8 g/day, initially, for up to 2 wk. Subsequent doses are based on patient response. CHILDREN: PO 75 to 100 mg/kg/day.

Transient Ischemic Attacks in Men

ADULTS: PO 1300 mg/day in 2 to 4 doses.

Myocardial Infarction Prophylaxis

ADULTS: PO 160 to 325 mg/day.

Kawasaki Disease

CHILDREN: PO 80 to 180 mg/kg/day during acute febrile period; 10 mg/kg/day after fever resolves.

Contraindication ::

 Contraindications Hypersensitivity to salicylates or NSAIDs; hemophilia, bleeding ulcers or hemorrhagic states.

Drug Precautions ::

 Precautions

Pregnancy: Category D. Lactation: Excreted in breast milk. Children: Reye’s syndrome has been associated with aspirin administration to children (including teenagers) with acute febrile illness. Do not use without consulting physician. GI disorders: Can cause gastric irritation and bleeding. Hepatic impairment: May cause hepatotoxicity in patients with impaired liver function. Hypersensitivity: Reaction may include bronchospasm and generalized urticaria or angioedema; patients with asthma or nasal polyps have greatest risk. Renal impairment: May decrease renal function or aggravate kidney diseases. Surgical patients: Aspirin may increase risk of postoperative bleeding. If possible, avoid use 1 week before surgery.

Drug Side Effects ::

 Adverse Reactions

EENT: Dizziness; tinnitus. GI: Nausea; dyspepsia; heartburn; bleeding. HEMA: Increased bleeding times; anemia; decreased iron concentration. OTHER: Hypersensitivity reactions may include urticaria, hives, rashes, angioedema and anaphylactic shock.

Drug Mode of Action ::  

 Action Inhibits prostaglandin synthesis, resulting in analgesia, anti-inflammatory activity and platelet aggregation inhibition; reduces fever by acting on the brain’s heat-regulating center to promote vasodilation and sweating.

Drug Interactions ::

 Interactions

Alcohol: May increase risk of GI ulceration and prolong bleeding time. Antacids, urinary alkalinizers, and corticosteroids: May decrease aspirin levels. Anticoagulants, oral and heparin: May increase risk of bleeding. Carbonic anhydrase inhibitors (eg, acetohexamide), methotrexate, valproic acid: May increase levels of these drugs. Probenecid, sulfinpyrazone: May decrease uricosuric effect. Sulfonylureas, insulin: Aspirin (> 2 g/day) may potentiate glucose lowering.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies, particularly to tartrazine (yellow dye #5). Note asthma, hay fever, and nasal polyps.
• Ensure that bleeding time and prothrombin time have been evaluated before beginning large dose long-term therapy.
• Monitor hemoglobin or guaiac (hemoccult) stool periodically during therapy.
• Monitor during long-term therapy for tinnitus, GI disturbances, bleeding from gums, black tarry stools, or prolonged fever lasting > 3 days.
• If signs of bleeding, black tarry stools, or tinnitus occur, withhold medication and notify physician.
• Observe for rash, urticaria, dyspnea, or anaphylactic reaction. If these occur, notify physician immediately.

Drug Storage/Management ::

 Administration/Storage

• Administer after meals, with food or antacid to minimize gastric irritation.
• Do not crush or have patient chew enteric-coated or timed-release caplets.
• Store oral forms at room temperature in tightly closed container. Store suppositories in a cool location or refrigerate. Do not freeze.

Drug Notes ::

 Patient/Family Education

• Instruct patient to take drug with food or after meals and with full glass of water. Explain that antacids should be avoided within 1 to 2 hr after ingestion of enteric-coated tablets.
• Tell patient to discard any aspirin that has a vinegar-like odor.
• Instruct patient to report ringing in ears or unusual bleeding, bruising, or persistent GI pain.
• Advise patient on long-term therapy to inform physician or dentist before seeking surgery or dental care.
• Tell patient on sodium-restricted diet to limit use of effervescent or buffered aspirin preparations.
• Caution parents to avoid giving aspirin to children or teenagers with flu-like symptoms or chickenpox without first consulting physician.
• Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.