Details About Generic Salt ::  Dopamine

Main Medicine Class:: Vasopressor   

(DOE-puh-meen HIGH-droe-KLOR-ide)

Intropin,  Revimine

Class: Vasopressor

Drugs Class ::

 Action Stimulates beta₁ receptors in heart, causing more complete and forceful contractions (inotropy). Also acts on alpha receptors (dose dependent) and has dopaminergic effects.

Indications for Drugs ::

 Indications Correction of hemodynamic imbalances present in shock after MI; trauma, endotoxic septicemia, surgery and renal failure or imbalances in conditions of chronic refractory cardiac decompensation (eg, CHF).

Drug Dose ::

 Route/Dosage

ADULTS: IV Initial dose: 2 to 5 mcg/kg/min with incremental changes of 5 to 10 mcg/kg/min at 10 to 15 min intervals until adequate response is noted. Most patients are maintained at < 20 mcg/kg/min. If dosage exceeds 50 mcg/kg/min, assess renal function frequently.

Contraindication ::

 Contraindications Pheochromocytoma; uncorrected tachyarrhythmias; ventricular fibrillation.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Special risk patients: Do not give in presence of uncorrected tachyarrhythmias or ventricular fibrillation. Extravasation: Avoid by infusing into large vein and monitoring infusion carefully. Sulfite sensitivity: Use caution in sulfite-sensitive individuals; some commercial preparations contain sodium bisulfite.

Drug Side Effects ::

 Adverse Reactions

CV: Ectopic beats; tachycardia; anginal pain; palpitation; hypotension; vasoconstriction; ventricular arrhythmias (at high doses); hypertension. CNS: Headache; anxiety. EENT: Dilated pupils (at high doses). GI: Nausea; vomiting. GU: Decreased urine output. RESP Dyspnea. OTHER: Gangrene of extremities.

Drug Mode of Action ::  

 Action Stimulates beta₁ receptors in heart, causing more complete and forceful contractions (inotropy). Also acts on alpha receptors (dose dependent) and has dopaminergic effects.

Drug Interactions ::

 Interactions

Furazolidone, methyldopa, rauwolfia alkaloids: Hypertension may result. Guanethidine: Antihypertensive effects of guanethidine may be negated. Monoamine oxidase inhibitors: May greatly increase pressor response from dopamine. Phenytoin: Severe hypotension and bradycardia may result after concomitant administration with dopamine. Tricyclic antidepressants: May decrease pressor response from dopamine. Incompatibilities: Chemically incompatible with alkaline solutions (drug is inactivated).

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Monitor vital signs and ECG closely throughout therapy.
• Monitor I&O regularly. Notify physician promptly if urine output decreases.
• Monitor IV rate for free flow throughout administration.
• Monitor central venous pressure or pulmonary wedge pressure if possible during infusion.
• Observe infusion site for extravasation. If extravasation occurs, treat by infiltrating the area with 10 to 15 ml of normal saline containing 5 to 10 mg of phentolamine.
• Notify physician immediately if these signs occur: significant changes in vital signs, ECG changes (arrhythmias, tachycardia); deterioration of peripheral pulses and cold, mottled extremities.

Drug Storage/Management ::

 Administration/Storage

• Administer by IV infusion only. Metering device is essential for controlling rate of flow.
• Dopamine is potent drug. Dilute before use if not prediluted.
• Dilute medication just prior to administration. Solution is stable for 24 hr after dilution.
• Do not use if solution is discolored.
• Store at room temperature and protect from light. Discard dissolved solution.

Drug Notes ::

 Patient/Family Education

• Instruct patient to inform nurse immediately if these signs occur: chest pain, dyspnea, numbness, tingling or burning of extremities and discomfort at IV site.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.