The Brand Name ACTIFED Has Generic Salt :: PSEUDOEPHEDRINE 

ACTIFED  Is From Company Gsk Priced :: Rs. 6.9

ACTIFED have PSEUDOEPHEDRINE is comes under Sub class Anti Histamines and Nasal Decongestants of  Main Class Respiratory System

Main Medicine Class:: Respiratory System  Sub Medicine Class :: Anti Histamines and Nasal Decongestants 

Indications for Drugs ::

Nasal congestion

Drug Dose ::

As a decongestant and symptomatic treatment for upper respiratory tract infections the recommended dose is: Adults : 1 tablet every 4 to 6 hours, up to maximum of 240 mg in 24 hours Children : (6 – 12 years of age) 1/2 tablet every 4 to 6 hours daily (2 – 5 years of age) 1/4 tablet every 4 to 6 hours daily For children less than 2 years of age, the drug is not advised unless specifically recommended by a physician.

Contraindication ::

Pseudoephedrine is contraindicated in * Hypersensitivity of individuals to this drug * Severe hypertension and coronary artery disease * Concurrent use of Mono Amine Oxidase Inhibitor (MAOI) drugs

Drug Precautions ::

Although Pseudoephedrine has virtually no pressor effects in normotensive patients, it should be used with caution in patients suffering mild to moderate hypertension. As with other sympathomimetic agents, Pseudoephedrine should be used with caution in patients with hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure and prostatic enlargement. Caution should be exercised when using the product in the presence of severe hepatic impairment or moderate to severe renal impairment.

Drug Side Effects ::

Serious adverse effects associated with the use of Pseudoephedrine are rare. Symptoms of central nervous system excitation may occur, including sleep disturbances and, rarely, hallucinations have been reported. Skin rashes, with or without irritation, have occasionally been reported.

Pregnancy category ::

3

Drug Mode of Action ::  

Pseudoephedrine is both an alpha-and beta-adrenergic receptor agonist. It causes vasoconstriction via direct stimulation of alpha-adrenergic receptors of the respiratory mucosa. It also directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

Drug Interactions ::

Increased risk of hypertension and arrhythmias if given with cardiac glycosides, quinidine or TCAs. Increased risk of vasoconstrictor effects if given with ergot alkaloids or oxytocin. Co-admin with MAOIs may cause hypertensive crisis. Anaesthetics e.g. cyclopropane, halothane and other halogenated anaesthestics; antihypertensive agents.