The Brand Name EMPETUS Has Generic Salt :: Ritonavir 

EMPETUS  Is From Company EMCURE(ARV) Priced :: Rs. 890

EMPETUS have Ritonavir is comes under Sub class Anti Retrovirals (Drugs for HIV) of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Anti Retrovirals (Drugs for HIV) 

Indications for Drugs ::

HIV infection, AIDS

Drug Dose ::

Adult: PO HIV infection Combined w/ other antiretrovirals: Initial: 300 mg twice daily for 1 day. May increase gradually over a period of up to 14 days to 600 mg twice daily. As a pharmacokinetic enhancer 100-200 mg 1-2 times/day.

Contraindication ::

Hypersensitivity; lactation; severe hepatic impairment.

Drug Precautions ::

Pregnancy; child; hepatic impairment; DM; haemophilia; pancreatitis. Monitor glucose, lipid, uric acid and blood counts. Ensure adequate hydration to reduce risk of nephrolithiasis. Discontinue treatment if patient develops haemolytic anaemia.

Drug Side Effects ::

Syncope, orthostatic hypotension; dry mouth, mouth ulcers, throat irritation, cough; dyspepsia, nausea, vomiting, diarrhoea, taste disturbance, seizures, anxiety, sweating, fever, asthenia, fatigue, headache, dizziness, paraesthesia, myalgia, skin rashes, pruritus, renal insufficiency, anaemia, raised WBC, raised prothrombin time, lipodystrophy, pancreatitis, electrolyte imbalance. Potentially Fatal: Hypersensitivity, anaphylaxis and Stevens-Johnson syndrome.

Pregnancy category ::

2

Drug Mode of Action ::  

Ritonavir, a selectively competitive reversible inhibitor of HIV protease, interferes with the formation of essential proteins and enzymes. Afterwhich, the formation of immature and non-infectious viruses follows. It also interferes with the production of infectious HIV and limits further infectious spread of the virus.

Drug Interactions ::

Decreased plasma conc with phenobarbital, carbamazepine, dexamethasone, phenytoin, rifabutin and rifampicn. Increased plasma conc of certain drugs highly metabolized by CYP3A. May increase serum levels of sildenafil. Potentially Fatal: Avoid concurrent admin of oral solution (contains alcohol) with disulfiram or metronidazole. Increased risk of myopathy when used with simvastatin or lovastatin. Concurrent use with alfuzosin may lead to serious hypotension. Increased risk of cardiac arrhythmias when used with amiodarone, cisapride, propafenone, quinidine, flecainide and pimozide. Risk of acute ergot toxicity when used with ergot derivatives. Increased risk of serious adverse reactions when used with midazolam or triazolam.