The Brand Name LEDERMYCIN Has Generic Salt :: Demeclocycline 

LEDERMYCIN  Is From Company Wyeth Priced :: Rs. 19.93

LEDERMYCIN have Demeclocycline is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Atypical pneumonia, Hyponatraemia

Drug Dose ::

Adult: PO Susceptible infections 150 mg 4 times/day. Atypical pneumonia 300 mg 3 times/day. Chronic hyponatraemia associated w/ SIADH Initial: 900-1,200 mg/day in divided doses. Maintenance: 600-900 mg/day in divided doses.

Contraindication ::

Hypersensitivity. Pregnancy and lactation.

Drug Precautions ::

Children <12 yr; SLE; renal or hepatic disease. Drug Side Effects ::

Photosensitivity. Reversible nephrogenic diabetes insipidus. Permanent staining of teeth; nausea; rash; GI upsets; dysphagia; enterocolitis; anogenital inflammation (moniliasis). Hypersensitivity; haemolytic anaemia, thrombocytopenia, neutropenia and eosinophilia; raised blood urea and liver enzymes. Potentially Fatal: Anaphylaxis (rare).

Pregnancy category ::

4

Drug Mode of Action ::  

Demeclocycline inhibits protein synthesis by binding w/ the 30S and possibly the 50S ribosomal subunits of susceptible bacteria. It may also cause alterations in the cytoplasmic membrane. It inhibits the action of antidiuretic hormone (ADH) in patients w/ chronic syndrome of inappropriate antidiuretic hormone secretion (SIADH).

Drug Interactions ::

Reduced absorption w/ antacids containing Al, Mg, or Ca, Fe-containing preparations, zinc, kaolin, quinapril, strontium ranelate, sucralfate, tripotassium dicitratobismuthate. May reduce the efficacy of oral contraceptives and penicillins. Increased risk of benign intracranial HTN w/ retinoids (e.g. acitretin, isotretinoin, tretinoin). Increased risk of ergotism w/ ergotamine and methysergide. May inactivate oral typhoid vaccine. May potentiate the effect of anticoagulants. Potentially Fatal: Concurrent use w/ methoxyflurane may result to fatal renal toxicity.