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OSTRON 10 4MG

The Brand Name OSTRON Has Generic Salt :: Ondansetron 

OSTRON  Is From Company Aabtac Life Priced :: Rs. 39

OSTRON have Ondansetron is comes under Sub class Anti Emetics of  Main Class Gastrointestinal System

Main Medicine Class:: Gastrointestinal System  Sub Medicine Class :: Anti Emetics 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Ondansetron  TAB  Rs. 39  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 OSTRON  Aabtac Life  4MG  10 Rs. 39

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Aabtac Life :: OSTRON  Ondansetron  Gastrointestinal System Anti Emetics

Indications for Drugs ::

Post-op nausea and vomiting, Nausea and vomiting associated w/ cancer chemotherapy

Drug Dose ::

1. Prevention of nausea-vomiting associated with chemotherapy 1 a. Adult Parenteral: 32 mg single dose infused over 15 minutes by diluting with 50 ml saline (5% dextrose or 0.9% NaCl) 30 minutes before starting chemotherapy. Alternative therapy: Three dose of 0.15 mg/kg body weight. The first dose is infused over 15 minutes beginning 30 minutes before the starting chemotherapy. Subsequent doses (0.15 mg/kg) are administered 4 and 8 hours after the first dose of administration. Oral: Highly emetogenic cancer chemotherapy: 24 mg (three 8 mg tablet/oral film) administered 30 minutes before start of emetogenic chemotherapy Moderate emetogenic cancer chemotherapy: 8 mg (one 8 mg tablet/oral film) administered 30 minutes before start of emetogenic chemotherapy. A further 8 mg dose should be administered after 8 hours of the first dose. One 8 mg tablet/oral film should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy. 1 b. Pediatric Parenteral (6 months onwards): Three dose of 0.15 mg/kg body weight. The first dose is infused over 15 minutes beginning 30 minutes before starting moderately to highly emetogenic chemotherapy. Subsequent doses (0.15 mg/kg) are administered 4 and 8 hours after the first dose of administration. Oral (4-11 years): 4 mg tablet/oral film should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. Then 4 mg tablet/oral film should be administered 3 times a day (every 8 hours) for 1-2 days after completion of chemotherapy. 2. Prevention of nausea-vomiting associated with radiotherapy Adults/ Geriatric/ Child of 12 years or over The recommended dose is 8 mg tablet/oral film 3 times a day. For total body irradiation: One 8 mg tablet/oral film should be administered 1 to 2 hours before each fraction of radiotherapy administered each day. For single high-dose fraction radiotherapy to the abdomen: One 8 mg tablet/oral film should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy. For daily fractionated radiotherapy to the abdomen: One 8 mg tablet/oral film should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day. 3. Prevention of post-operative nausea-vomiting 3 a. Adults/ Geriatric/ Child of 12 years or over Parenteral : Undiluted 4 mg intravenously or intramuscularly immediately before induction of anesthesia. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. Alternatively, the dose can be administered post-operatively if the patient experiences nausea and/or vomiting shortly after surgery Oral: 16 mg (two 8 mg tablets/oral film) 1 hour before induction of anesthesia. 3 b. Pediatric (1 months to12 years) Parenteral : Weighing less than 40 kg: 0.1-mg/kg body weight in a Single dose . Weighing more than 40 kg: 4mg single dose The dose should be immediately before induction of anesthesia. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. Alternatively, the dose can be administered post-operatively if the patient experiences nausea and/or vomiting shortly after surgery. 4. Nausea-vomiting in gastroenteritis 4 a. Adult: 8 mg three times daily. 4 b. Pediatric (1 month or over): 0.15 mg/kg body weight three times daily. 5. Nausea vomiting in pregnancy 8 mg (1 tablet) 2-3 times daily

Contraindication ::

Use with apomorphine (profound hypotension).

Drug Precautions ::

May cause QT prolongation; caution when used in cardiac diseases, patients who are on medications that can prolong QT or patients with electrolyte abnormalities. Severe hepatic impairment. May mask progressive ileus and/or gastric distension. Pregnancy, lactation.

Drug Side Effects ::

Headache, malaise/fatigue, constipation; drowsiness, fever, dizziness, anxiety, cold sensation; pruritus, rash; diarrhoea; gynaecological disorder, urinary retention; elevated transaminase; local inj site reaction (pain, redness, burning); paresthesia; hypoxia. Rarely: Anaphylaxis, angina, bronchospasm, ECG changes, extrapyramidal symptoms, grand mal seizure, hypokalaemia, tachycardia, vascular occlusive events.

Pregnancy category ::
Pregnancy category

2

Drug Mode of Action ::  

Ondansetron antagonises selective 5-HT3-receptor, blocking serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. This action of ondansetron gives it its antiemetic property to prevent emesis due to acute chemotherapy mediated by serotonin.

Drug Interactions ::

May reduce analgesic effect of tramadol. Rifampicin and other CYP3A4 inducers may reduce levels/effects of ondansetron. Concomitant use of QT-prolonging agents (e.g. antiarrhythmics) may cause additive prolongation of QT interval. May increase the risk of arrhythmias w/ cardiotoxic drugs (e.g. anthracyclines). Potentially Fatal: May increase the hypotensive effect of apomorphine.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

OSTRON 30ML 2MG/5ML

The Brand Name OSTRON Has Generic Salt :: Ondansetron 

OSTRON  Is From Company Aabtac Life Priced :: Rs. 25

OSTRON have Ondansetron is comes under Sub class Anti Emetics of  Main Class Gastrointestinal System

Main Medicine Class:: Gastrointestinal System  Sub Medicine Class :: Anti Emetics 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Ondansetron  SYR  Rs. 25  30ML
Brand Name Company / Manufacturers Strength Unit Price / 30ML
 OSTRON  Aabtac Life  2MG/5ML  30ML Rs. 25

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Aabtac Life :: OSTRON  Ondansetron  Gastrointestinal System Anti Emetics

Indications for Drugs ::

Post-op nausea and vomiting, Nausea and vomiting associated w/ cancer chemotherapy

Drug Dose ::

1. Prevention of nausea-vomiting associated with chemotherapy 1 a. Adult Parenteral: 32 mg single dose infused over 15 minutes by diluting with 50 ml saline (5% dextrose or 0.9% NaCl) 30 minutes before starting chemotherapy. Alternative therapy: Three dose of 0.15 mg/kg body weight. The first dose is infused over 15 minutes beginning 30 minutes before the starting chemotherapy. Subsequent doses (0.15 mg/kg) are administered 4 and 8 hours after the first dose of administration. Oral: Highly emetogenic cancer chemotherapy: 24 mg (three 8 mg tablet/oral film) administered 30 minutes before start of emetogenic chemotherapy Moderate emetogenic cancer chemotherapy: 8 mg (one 8 mg tablet/oral film) administered 30 minutes before start of emetogenic chemotherapy. A further 8 mg dose should be administered after 8 hours of the first dose. One 8 mg tablet/oral film should be administered twice a day (every 12 hours) for 1-2 days after completion of chemotherapy. 1 b. Pediatric Parenteral (6 months onwards): Three dose of 0.15 mg/kg body weight. The first dose is infused over 15 minutes beginning 30 minutes before starting moderately to highly emetogenic chemotherapy. Subsequent doses (0.15 mg/kg) are administered 4 and 8 hours after the first dose of administration. Oral (4-11 years): 4 mg tablet/oral film should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. Then 4 mg tablet/oral film should be administered 3 times a day (every 8 hours) for 1-2 days after completion of chemotherapy. 2. Prevention of nausea-vomiting associated with radiotherapy Adults/ Geriatric/ Child of 12 years or over The recommended dose is 8 mg tablet/oral film 3 times a day. For total body irradiation: One 8 mg tablet/oral film should be administered 1 to 2 hours before each fraction of radiotherapy administered each day. For single high-dose fraction radiotherapy to the abdomen: One 8 mg tablet/oral film should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for 1 to 2 days after completion of radiotherapy. For daily fractionated radiotherapy to the abdomen: One 8 mg tablet/oral film should be administered 1 to 2 hours before radiotherapy, with subsequent doses every 8 hours after the first dose for each day. 3. Prevention of post-operative nausea-vomiting 3 a. Adults/ Geriatric/ Child of 12 years or over Parenteral : Undiluted 4 mg intravenously or intramuscularly immediately before induction of anesthesia. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. Alternatively, the dose can be administered post-operatively if the patient experiences nausea and/or vomiting shortly after surgery Oral: 16 mg (two 8 mg tablets/oral film) 1 hour before induction of anesthesia. 3 b. Pediatric (1 months to12 years) Parenteral : Weighing less than 40 kg: 0.1-mg/kg body weight in a Single dose . Weighing more than 40 kg: 4mg single dose The dose should be immediately before induction of anesthesia. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes. Alternatively, the dose can be administered post-operatively if the patient experiences nausea and/or vomiting shortly after surgery. 4. Nausea-vomiting in gastroenteritis 4 a. Adult: 8 mg three times daily. 4 b. Pediatric (1 month or over): 0.15 mg/kg body weight three times daily. 5. Nausea vomiting in pregnancy 8 mg (1 tablet) 2-3 times daily

Contraindication ::

Use with apomorphine (profound hypotension).

Drug Precautions ::

May cause QT prolongation; caution when used in cardiac diseases, patients who are on medications that can prolong QT or patients with electrolyte abnormalities. Severe hepatic impairment. May mask progressive ileus and/or gastric distension. Pregnancy, lactation.

Drug Side Effects ::

Headache, malaise/fatigue, constipation; drowsiness, fever, dizziness, anxiety, cold sensation; pruritus, rash; diarrhoea; gynaecological disorder, urinary retention; elevated transaminase; local inj site reaction (pain, redness, burning); paresthesia; hypoxia. Rarely: Anaphylaxis, angina, bronchospasm, ECG changes, extrapyramidal symptoms, grand mal seizure, hypokalaemia, tachycardia, vascular occlusive events.

Pregnancy category ::
Pregnancy category

2

Drug Mode of Action ::  

Ondansetron antagonises selective 5-HT3-receptor, blocking serotonin, both peripherally on vagal nerve terminals and centrally in the chemoreceptor trigger zone. This action of ondansetron gives it its antiemetic property to prevent emesis due to acute chemotherapy mediated by serotonin.

Drug Interactions ::

May reduce analgesic effect of tramadol. Rifampicin and other CYP3A4 inducers may reduce levels/effects of ondansetron. Concomitant use of QT-prolonging agents (e.g. antiarrhythmics) may cause additive prolongation of QT interval. May increase the risk of arrhythmias w/ cardiotoxic drugs (e.g. anthracyclines). Potentially Fatal: May increase the hypotensive effect of apomorphine.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

LEVAB 10 500MG

The Brand Name LEVAB Has Generic Salt :: Levofloxacin 

LEVAB  Is From Company Aabtac Life Priced :: Rs. 92.5

LEVAB have Levofloxacin is comes under Sub class Quinolones of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Quinolones 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Levofloxacin  TAB  Rs. 92.5  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 LEVAB  Aabtac Life  500MG  10 Rs. 92.5

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Aabtac Life :: LEVAB  Levofloxacin  Anti Infectives Quinolones

Indications for Drugs ::

Chronic bronchitis, Acute bacterial sinusitis, Anthrax, Community-acquired pneumonia, Skin and skin structure infections, Nosocomial pneumonia, Urinary tract infections, Complicated skin and skin structure infections, Acute pyelonephritis, Chronic bacterial prostatitis

Drug Dose ::

Adult: PO/IV Acute sinusitis 500 mg once daily for 10-14 days. Acute bacterial exacerbation of chronic bronchitis 500 mg once daily for 7 days. Community-acquired pneumonia 500 mg once daily for 7-14 days. Uncomplicatd skin infections 500 mg once daily for 7-10 days. Nosocomial pneumonia; Complicated skin infections 750 mg once daily for 7-14 days. Uncomplicated UTI 250 mg once daily for 3 days. Acute pyelonephritis; Complicated UTI 250 mg once daily for 10 days. Chronic bacterial prostatitis 500 mg once daily for 28 days. Treatment and postexposure prophylaxis of inhalation anthrax 500 mg once daily for 60 days. Children – Children 6 months to <5 years: 10 mg/kg every 12 hours - Children > 5 years:10 mg/kg every 24 hours Renal impairment: Haemodialysis/CAPD: Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr. CrCl (ml/min) 20-49 Initially, 500 mg daily, then 250 mg every 24 hr. Alternatively: Initially, 750 mg daily, then 750 mg every 48 hr. 10-19 Initially, 500 mg daily, then 250 mg every 48 hr. Alternatively: Initially, 750 mg daily, then 500 mg every 48 hr.

Contraindication ::

Hypersensitivity to levofloxacin or other quinolones. Child <18 yr. Drug Precautions ::

Known or suspected CNS disorders (e.g. severe cerebral arteriosclerosis, epilepsy) or other risk factors that predispose to seizures. Avoid unnecessary exposure to sunlight or artificial UV light. History of prolonged QT interval, uncorrected electrolyte disturbances. DM (carefully monitor blood glucose levels). Periodically monitor renal, hepatic and haematopoietic functions during treatment. Pregnancy and lactation. Elderly. May impair ability to drive or operate machinery.

Drug Side Effects ::

Oral/IV: Nausea, diarrhoea, constipation, headache, insomnia, inj site reactions (IV). Ophthalmic: Transient decrease in vision, ocular burning, ocular pain or discomfort, foreign body sensation, headache, fever, pharyngitis, photophobia. Potentially Fatal: Anaphylaxis.

Pregnancy category ::
Pregnancy category

3

Drug Mode of Action ::  

Levofloxacin exerts antibacterial action by inhibiting bacterial topoisomerase IV and DNA gyrase, the enzymes required for DNA replication, transcription repair and recombination. It has in vitro activity against a wide range of gram-negative and gram-positive microorganisms.

Drug Interactions ::

Additive effects on QT interval prolongation w/ class IA (e.g. quinidine, procainamide) or class III (amiodarone, sotalol) antiarrhythmics, fluoxetine or imipramine. Reduced absorption w/ sucralfate, didanosine, antacids containing Mg or Al, dietary supplements containing Zn, Ca, Mg or Fe. Altered glucose levels w/ antidiabetic agents (e.g. insulin, glibenclamide). Increased risk of severe tendon disorders w/ corticosteroids. Increased risk of CNS stimulation and seizures w/ NSAIDs. Increased prothrombin time w/ warfarin.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DROXIB 10 250/500;MG

The Brand Name DROXIB Has Generic Salt :: Cefadroxil 

DROXIB  Is From Company Aabtac Life Priced :: Rs. 42.50/76.90

DROXIB have Cefadroxil is comes under Sub class Cephalosporins of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Cephalosporins 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Cefadroxil  TAB  Rs. 42.50/76.90  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 DROXIB  Aabtac Life  250/500;MG  10 Rs. 42.50/76.90

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Aabtac Life :: DROXIB  Cefadroxil  Anti Infectives Cephalosporins

Indications for Drugs ::

Pharyngitis, Susceptible infections, Sore throat, Tonsillitis, Urinary tract infection, Reproductive tract infection and skin infections

Drug Dose ::

Adult: PO 1-2 g/day as a single dose or in 2 divided doses. Children: 30 mg/kg/day in equally divided doses every 12 hours. Renal impairment: CrCl (ml/min) 26-50 0.5-1 g bid. 11-25 0.5-1 g once daily. <10 0.5-1 g every 36 hr. Contraindication ::

Hypersensitivity to cephalosporins.

Drug Precautions ::

Impaired renal function; pregnancy and lactation.

Drug Side Effects ::

Nausea, vomiting, diarrhoea, abdominal discomfort; skin rash, angioedema; elevated liver enzyme values; superinfection with resistant organisms especially candida. Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Pregnancy category ::
Pregnancy category

2

Drug Mode of Action ::  

Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.

Drug Interactions ::

Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

DROXIB 30ML 125MG

The Brand Name DROXIB Has Generic Salt :: Cefadroxil 

DROXIB  Is From Company Aabtac Life Priced :: Rs. 30

DROXIB have Cefadroxil is comes under Sub class Cephalosporins of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Cephalosporins 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Cefadroxil  D.SYR  Rs. 30  30ML
Brand Name Company / Manufacturers Strength Unit Price / 30ML
 DROXIB  Aabtac Life  125MG  30ML Rs. 30

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Aabtac Life :: DROXIB  Cefadroxil  Anti Infectives Cephalosporins

Indications for Drugs ::

Pharyngitis, Susceptible infections, Sore throat, Tonsillitis, Urinary tract infection, Reproductive tract infection and skin infections

Drug Dose ::

Adult: PO 1-2 g/day as a single dose or in 2 divided doses. Children: 30 mg/kg/day in equally divided doses every 12 hours. Renal impairment: CrCl (ml/min) 26-50 0.5-1 g bid. 11-25 0.5-1 g once daily. <10 0.5-1 g every 36 hr. Contraindication ::

Hypersensitivity to cephalosporins.

Drug Precautions ::

Impaired renal function; pregnancy and lactation.

Drug Side Effects ::

Nausea, vomiting, diarrhoea, abdominal discomfort; skin rash, angioedema; elevated liver enzyme values; superinfection with resistant organisms especially candida. Potentially Fatal: Anaphylactic reaction; pseudomembranous colitis.

Pregnancy category ::
Pregnancy category

2

Drug Mode of Action ::  

Cefadroxil binds to one or more of the penicillin-binding proteins (PBPs) which inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death. Cefadroxil is not active against Proteus, Pseudomonas, Enterobacter, Morganella, Serratia and Listeria monocytogenes.

Drug Interactions ::

Concomitant use w/ bacteriostatic antibiotics (e.g. tetracycline, erythromycin, sulfonamides, chloramphenicol) may cause antagonistic effect. May potentiate nephrotoxic effects of aminoglycoside antibiotics, polymyxin B, colistin or high-dose loop diuretics. May enhance the anticoagulant effect of vit K antagonists. May diminish the therapeutic effect of BCG, typhoid vaccine and Na picosulfate. May attenuate the effect of oral contraceptives. Increased serum concentration w/ probenecid. Reduced bioavailability w/ colestyramine.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

CIPROB 10 250/500;MG

The Brand Name CIPROB Has Generic Salt :: Ciprofloxacin 

CIPROB  Is From Company Aabtac Life Priced :: Rs. 29.00/49.50

CIPROB have Ciprofloxacin is comes under Sub class Quinolones of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Quinolones 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Ciprofloxacin  TAB  Rs. 29.00/49.50  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 CIPROB  Aabtac Life  250/500;MG  10 Rs. 29.00/49.50

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Aabtac Life :: CIPROB  Ciprofloxacin  Anti Infectives Quinolones

Indications for Drugs ::

Cystic fibrosis, Intra-abdominal infections, Meningitis, Peritonitis, Endocarditis, Anthrax, Otitis media, Septicaemia, Lower Respiratory Tract Infections, Cystitis, Gonorrhoea, Skin and skin structure infections, Nosocomial pneumonia, Urinary tract infections, Enteric fever, Bone and Joint Infections, Biliary tract infections, Surgical Prophylaxis, Gastroenteritis, Q fever, Acute Sinusitis, Cat scratch disease, Spotted fever, Typhus, Chanroid, Brucellosis, Typhoid and paratyphoid fever, Superficial ophthalmic infections, Otitis externa

Drug Dose ::

Adult Dose: For oral dosage & suspension: Urinary Tract infection: Acute uncomplicated: 250 mg twice daily for 3 days; Mild/Moderate: 250 mg twice daily for 7 to 14 days; Severe/Complicated: 500 mg twice daily for 7 to 14 days; Chronic Bacterial Prostitis : 500 mg twice daily for 28 days; Lower Respiratory Tract infection: Mild/Moderate: 500 mg twice daily for 7 to 14 days, Severe/Complicated : 750 mg twice daily for 7 to 14 days; Acute Sinusitis : 500 mg twice daily for 10 days; Skin and Skin Structure infection: Mild/Moderate : 500 mg twice daily for 7 to 14 days, Severe/Complicated : 750 mg twice daily for 7 to 14 days, Bone and joint infection: Mild/Moderate 500 mg twice daily for 4 to 6 weeks, Severe/Complicated : 750 mg twice daily for 4 to 6 weeks, Intra Abdominal Infection: 500 mg twice daily for 7 to 14 days, Infectious Diarrhea: Mild/Moderate/Severe: 500 mg twice daily for 5 to 7 days, Typhoid Fever : 500 mg twice daily for 10 days, Urethral & Cervical Gonococcal Infections: Uncomplicated: 250 mg Single dose. For IV infusion : Urinary Tract Infection: Mild to Moderate: 200 mg 12 hourly for 7-14 days;Severe or Complicated: 400 mg 12 hourly for 7-14 days; Lower Respiratory Tract infection: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days; Nosocomial Pneumonia: Mild/Moderate/Severe: 400 mg 8 hourly for 10-14 days; Skin and Skin Structure: Mild to Moderate: 400 mg 12 hourly for 7-14 days; Severe or Complicated: 400 mg 8 hourly for 7-14 days; Bone and Joint Infection: Mild to Moderate: 400 mg 12 hourly for more than 4-6 weeks; Severe/Comlicated: 400 mg 8 hourly for more than 4-6weeks; Intra abdominal (Acute abdomen): Complicated: 400 mg 12 hourly for 7-14 days; Acute Sinusitis: Mild/Moderate: 400 mg 12 hourly for10 days: Chronic Bacterial Prostatitis: Mild/Moderate: 400 mg 12 hourly for 28 Days. Children and adolescents: RTI & GI infections: Neonate-15mg/kg twice daily, Child (1 month -18 years)-20mg/kg (max 750 mg) twice daily; UTI: Neonate-10 mg/kg twice daily, Child (1 month -18 years)-10mg/kg (max 750 mg) twice daily; Pseudomonal lower respiratory tract infection in cystic fibrosis: Child (1 month -18 years) – 20mg/kg (max 750 mg) twice daily; Anthrax (treatment & post exposure prophylaxis): Child (1 month -18 years) – 20mg/kg (max 750 mg) twice daily.

Contraindication ::

Hypersensitivity. Not to be used concurrently with tizanidine. Avoid exposure to strong sunlight or sun lamps during treatment.

Drug Precautions ::

Epilepsy, history of CNS disorders; severe renal or hepatic dysfunction; G6PD deficiency; maintain adequate hydration; myasthaenia gravis. Caution when used in patients with QT prolongation or risk factors e.g. bradycardia, pre-existing cardiac disease or uncorrected electrolyte disturbances. Discontinue treatment if patients experience tendon pain, inflammation or rupture. Avoid usage in methicillin-resistant staphylococcus aureus (MRSA) infections due to high level of resistance. May impair ability to drive or operate machinery. Safety and efficacy have not been established in pregnant and lactating women. Not to be used in children <18 yr; except where benefit clearly exceeds risk. Drug Side Effects ::

GI disturbances; headache, tremor, confusion, convulsions; rashes; joint pain; phototoxicity. Transient increases in serum creatinine. Haematological, hepatic and renal disturbances. Vasculitis, pseudomembranous colitis and tachycardia. Phototoxicity. Potentially Fatal: Anaphylactoid reaction; cardiopulmonary arrest.

Pregnancy category ::
Pregnancy category

3

Drug Mode of Action ::  

Ciprofloxacin promotes breakage of double-stranded DNA in susceptible organisms and inhibits DNA gyrase, which is essential in reproduction of bacterial DNA.

Drug Interactions ::

May increase plasma concentrations of CYP1A2 substrates (e.g. clozapine, ropinirole, theophylline). Enhances effect of oral anticoagulants (e.g. warfarin) and glibenclamide. Increased toxicity of methotrexate. Plasma concentrations may be increased by probenecid. Reduced absorption w/ oral multivitamins and mineral supplements containing divalent or trivalent cations (e.g. Fe, Zn, Ca) and antacids containing Al, Ca or Mg. Concomitant use w/ class IA antiarrhythmics (e.g. quinidine, procainamide), class III antiarrhythmics (e.g. amiodarone, sotalol), TCAs, macrolides and antipsychotics may result in additive effects on QT interval prolongation. Concurrent use w/ corticosteroids may increase risk of severe tendon disorders. Increased risk of CNS stimulation w/ NSAIDs. Altered serum concentrations of phenytoin. Potentially Fatal: Marked elevation in serum levels of tizanidine which is associated w/ potentiated hypotensive and sedative effect.

 

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.