Details About Overdose or Poisoning Generic Salt :: Deferoxamine Deferoxamine Drug Pharmacology :: I. Pharmacology. Deferoxamineis a specific chelating agent for iron. It binds free iron and, to someextent, loosely bound iron (eg, from ferritin or hemosiderin). Ironbound to hemoglobin, transferrin, cytochrome enzymes, and all othersites is not affected. The red iron-deferoxamine...
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Details About Overdose or Poisoning Generic Salt :: Labetalol Labetalol Drug Pharmacology :: I. Pharmacology. Labetalolis a mixed alpha- and beta-adrenergic antagonist; after intravenousadministration, the nonselective beta-antagonist properties areapproximately sevenfold greater than the alpha-1 antagonist activity.Hemodynamic effects generally include decreases in heart rate, bloodpressure, and systemic vascular resistance. Atrioventricular conductionvelocity may be...
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Details About Overdose or Poisoning Generic Salt :: Thiosulfate, Sodium Thiosulfate, Sodium Drug Pharmacology :: I. Pharmacology. Sodiumthiosulfate is a sulfur donor that promotes the conversion of cyanideto the less toxic thiocyanate by the sulfur transferase enzymerhodanese. Unlike nitrites, thiosulfate is essentially nontoxic and maybe given empirically in suspected cyanide poisoning. Well-designedanimal...
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Details About Overdose or Poisoning Generic Salt :: Flumazenil Flumazenil Drug Pharmacology :: I. Pharmacology. Flumazenil(Romazicon) is a highly selective competitive inhibitor of CNSbenzodiazepine receptors. It has no demonstrable benzodiazepine agonistactivity and no significant toxicity even in high doses. It has noeffect on alcohol or opioid receptors, and it does not reverse...
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Details About Overdose or Poisoning Generic Salt :: Magnesium Magnesium Drug Pharmacology :: I. Pharmacology./b> Magnesiumis the fourth most common cation in the body and is the second mostabundant intracellular cation after potassium. Magnesium plays anessential role as an enzymatic cofactor in a number of biochemicalpathways, including energy production from adenosine...
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Details About Overdose or Poisoning Generic Salt :: Metoclopramide Metoclopramide Drug Pharmacology :: I. Pharmacology. Metoclopramideis a dopamine antagonist with antiemetic activity at the chemoreceptortrigger zone. It also accelerates GI motility and facilitates gastricemptying. The onset of effect is 1–3 minutes after intravenousadministration, and therapeutic effects persist for 1–2 hours after asingle...
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Details About Overdose or Poisoning Generic Salt :: Iodide, Potassium Iodide, KI Iodide (Potassium Iodide, KI) Drug Pharmacology :: I. Pharmacology. Iodine-131is a product of fission reactions and is likely to be a major form ofinternal radioactive contamination after a major nuclear reactoraccident or weapon detonation. Potassium iodide (KI) blocks thyroidgland uptake...
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Details About Overdose or Poisoning Generic Salt :: Ondansetron Ondansetron Drug Pharmacology :: I. Pharmacology. Ondansetron is a selective serotonin 5-HT3receptor antagonist with powerful antiemetic activity both centrally atthe chemoreceptor trigger zone and peripherally at vagal nerveterminals. The onset is about 30 minutes after an intravenous dose and60–90 minutes after an oral...
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Details About Overdose or Poisoning Generic Salt :: Apomorphine Apomorphine Drug Pharmacology :: I. Pharmacology. Apomorphineis an alkaloid salt derived from morphine that is a dopaminergicagonist with minimal analgesic properties but marked emetic efficacy.Vomiting is produced by direct stimulation of the medullarychemoreceptor trigger zone. After subcutaneous administration, emesisoccurs within an average of...
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Details About Overdose or Poisoning Generic Salt :: Pralidoxime, 2 PAM And Other Oximes Pralidoxime (2-PAM) and Other Oximes Drug Pharmacology :: I. Pharmacology. Oximesreverse acetylcholinesterase (AChE) inhibition by reactivating thephosphorylated cholinesterase enzyme and protecting the enzyme fromfurther inhibition. Although this effect is most pronounced withorganophosphate pesticides, positive clinical results have been...
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