The Brand Name LOTAS Has Generic Salt :: Losartan 

LOTAS  Is From Company TASMED Priced :: Rs. 20

LOTAS have Losartan is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Diabetic nephropathy, Hypertension, Stroke risk reduction of hypertensive or LVH patients, Heart Failure

Drug Dose ::

Hypertension: The usual starting dose is 50 mg once daily. In patients with possible depletion of intravascular volume or patients with a history of hepatic impairment, starting dose is 25 mg once daily. Losartan can be administered once or twice daily with total daily doses ranging from 25 mg to 100 mg. No initial dosage adjustment is necessary for elderly or renal impairment patients. Stroke risk reduction of hypertensive or LVH patients: Starting dose of Losartan is 50 mg once daily. Maximum dose upto 100 mg once daily. Diabetic Nephropathy: Starting dose of Losartan is 50 mg once daily. Maximum dose: 100 mg once daily. Heart Failure: Starting dose 12.5 mg once daily. The dose should generally be titrated at weekly intervals to maximum dose of 50 mg once daily. If blood pressure is not controlled by Losartan, a low dose of a diuretic (Hydrochlorothiazide) may be added. Chronic heart failure: 12.5 mg once daily, increased at weekly intervals to 50 mg once daily if tolerated, Stroke risk reduction in hypertension & LVH: 50 mg once daily. Hydrochlorothiazide 12.5 mg daily should added. Maximum dose-Losartan 100 mg followed by Hydrochlorothiazide 25 mg once daily. Nephropathy in type 2 Diabetes: 50 mg once daily. Maximum dose-100 mg once daily.

Contraindication ::

Losartan potassium is contraindicated in patients who are hypersensitive to the active ingredient or any component of the drug.

Drug Precautions ::

Patients with known hypersensitivity to the drugs that act through renin-angiotensin system. Special precaution should be taken when it is administered to the patients with renal and hepatic impairment. Safety and effectivenss of Losartan in pediatric patients have not been established.

Drug Side Effects ::

The most common adverse events occuring with Losartan are upper respiratory infection, dizziness and leg pain.

Pregnancy category ::

3

Drug Mode of Action ::  

Losartan is an angiotensin II receptor antagonist. It selectively and competitively blocks the vasoconstricting and aldosterone-secreting effects of angiotensin II by selectively antagonising its binding to AT1 receptors.

Drug Interactions ::

May decrease plasma levels / fluconazole and rifampicin. May increase serum lithium levels and toxicity. May antagonise hypotensive effect and increase risk of renal impairment w/ NSAIDs. Increased risk of hyperkalaemia w/ K-sparing diuretics (e.g. amiloride, triamterene, spironolactone), K supplements or K-containing salt substitutes. Potentially Fatal: May increase nephrotoxic, hyperkalaemic and hypotensive effect w/ aliskiren in patients w/ diabetes and renal impairment (GFR <60 mL/min).