Details About Generic Salt ::  Acetami1

Main Medicine Class:: Narcotic analgesic combination   

(ass-cet-ah-MEE-noe-fen with KOE-deen FOSS-fate)
Tylenol with Codeine, Margesic, Phenaphen with Codeine,  Acet Codeine, Empracet-30, Empracet-60, Emtec-30, Lenoltec No. 4, PMS-Acetaminophen with Codeine, Rounox with Codeine 15, Rounox with Codeine 30, Rounox with Codeine 60, Triatec-30, Tylenol with Codeine Elixir, Tylenol with Codeine No. 4
Class: Narcotic analgesic combination

 

Drugs Class ::

 Action Inhibits synthesis of prostaglandins; binds to opiate receptors in CNS and peripherally blocks pain impulse generation; produces antipyresis by direct action on hypothalamic heat-regulating center; causes cough suppression by direct central action in medulla; may produce generalized CNS depression; does not have significant anti-inflammatory or antiplatelet effects.

Indications for Drugs ::

 Indications Relief of mild-to-moderate pain; analgesic-antipyretic therapy in presence of aspirin allergy, hemostatic disturbances, bleeding diatheses, upper GI disease and gouty arthritis.

Drug Dose ::

 Route/Dosage

Tylenol No. 2 equals 15 mg codeine, 300 mg acetaminophen. Tylenol No. 3 equals 30 mg codeine, 300 mg acetaminophen. Tylenol No. 4 equals 60 mg codeine, 300 mg acetaminophen. Max adult dose: Codeine equals 360 mg/day; acetaminophen equals 4 g/day.

TABLETS

ADULTS: PO Usually 1 to 2 tablets q 4 hr (varies according to product). CHILDREN < 12 YR: PO 0.5 to 1 mg codeine/kg/dose q 4 to 6 hr; 10 to 15 mg acetaminophen/kg/dose q 4 hr to max of 2.6 g/24 hr.

ELIXIR

CHILDREN > 12 YR: PO 15 ml q 4 hr prn. CHILDREN 7 to 12 YR: PO 10 ml tid to qid prn. CHILDREN 3 to 6 YR: PO 5 ml tid to qid prn.

Contraindication ::

 Contraindications Hypersensitivity to codeine phosphate or similar compounds.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Sulfite sensitivity: Caution is needed with sulfite sensitive patients; some commercial preparations contain sodium bisulfite. Hepatic impairment: Acetaminophen intake must be limited to £ 2 g/day.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Flushing. CNS: Lightheadedness; dizziness; sedation; euphoria; insomnia; disorientation; uncoordination. DERM: Pruritus. GI: Nausea; vomiting; dry mouth; constipation; abdominal pain. RESP: Dyspnea; respiratory depression; decreased cough reflex. OTHER: Histamine release.

Drug Mode of Action ::  

 Action Inhibits synthesis of prostaglandins; binds to opiate receptors in CNS and peripherally blocks pain impulse generation; produces antipyresis by direct action on hypothalamic heat-regulating center; causes cough suppression by direct central action in medulla; may produce generalized CNS depression; does not have significant anti-inflammatory or antiplatelet effects.

Drug Interactions ::

 Interactions

Carbamazepine, hydantoins, sulfinpyrazone: May result in increased risk of hepatotoxicity. Cimetidine: Effects of codeine may be enhanced, increasing toxicity. CNS depressants (eg, barbiturates, ethyl alcohol, other narcotics): May result in additive CNS depressant effects and toxicity. Tricyclic antidepressants, phenothiazines: May cause additive CNS depressant effects and toxicity.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note pulmonary or hepatic disease, alcoholism, head injury, Addison’s disease, hypothyroidism, or previous addiction to narcotic drugs.
  • Assess baseline level of pain before administration.
  • Take vital signs before administration. Withhold dose if respiratory rate is < 12 breaths/min (< 20 in children) and notify physician.
  • Consider related factors that may lower pain threshold, such as anxiety, fear, boredom, or environmental stressors.
  • Assess cough for productiveness and effectiveness; auscultate for rales.
  • Administer scheduled dose before pain becomes severe.
  • Use the following adjunctive pain relief measures: Massage, emotional support, diversion.
  • If visual acuity is decreased by pupil constriction, keep room well lit during waking hours.
  • Assess therapeutic effectiveness 1 hr after administration of dose based on patient’s report of relief. Do not rely on objective signs.
  • Reassess respiratory rate, depth and rhythm after each dose. Notify physician if rate is < 10 breaths/min or breathing is shallow.
  • Assess for dizziness, sedation, euphoria, or confusion.
  • Monitor for urinary retention or constipation.
  • Monitor the following special-risk patients carefully: Elderly, debilitated, those with increased intracranial pressure, pulmonary disease or conditions involving hypoxia or hypercapnia, history of drug dependence.
  • Record degree and duration of pain relief. Notify physician if therapy is ineffective.
  • Record any adverse or unusual reactions.
  • If drowsiness or sedation occurs, institute safety precautions.
  • Provide diet high in fiber; increase fluids to 2 to 3 L unless contraindicated.
  • If constipation occurs, notify physician.
  • Encourage patient to void q 3 to 4 hr.
OVERDOSAGE: SIGNS & SYMPTOMS
  Blood dyscrasias, respiratory depression, hepatic damage (may occur up to several days after overdose)

Drug Storage/Management ::

 Administration/Storage

  • Give with food or milk if GI distress occurs.
  • Store in airtight, light-resistant container at room temperature.

Drug Notes ::

 Patient/Family Education

  • Caution patient that drug dependency or tolerance may result from long-term use.
  • Instruct patient not to discontinue medication abruptly after long-term regular use.
  • Caution patient to avoid intake of alcohol and other CNS depressants without consulting physician.
  • Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.
  • Instruct patient to notify physician if the following signs/symptoms occur: Persistence or recurrence of pain before next scheduled dose; difficulty breathing; blurred vision; increased drowsiness; severe nausea; vomiting; urinary retention; or yellowing of skin, sclera or gums.
  • Warn patient that orthostatic hypotension may occur; instruct patient to change positions slowly and to sit or lie down if symptoms occur.
  • Explain that diaphoresis is a common side effect and does not indicate a problem.
  • Warn patient that constipation may occur. Advise patient to increase dietary fiber and fluids unless contraindicated.
  • Caution patient against taking otc medications that contain acetaminophen.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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