Article Contents ::

Details About Generic Salt ::  Benzphet

Main Medicine Class:: CNS stimulant,Anorexiant   

(benz-FET-uh-meen HIGH-droe-KLOR-ide)
Didrex
Tablets: 25 mg, 50 mg
Class: CNS stimulant/Anorexiant

 Indications Short-term (few weeks) adjunct to diet plan to reduce weight.

 Contraindications Hypersensitivity to sympathomimetic amines; pregnancy; advanced arteriosclerosis; symptomatic cardiovascular disease; moderate to severe hypertension; hyperthyroidism; glaucoma; agitated states; history of drug abuse; during or within 14 days of MAOI use; coadministration with other CNS stimulants.

 Route/Dosage

ADULTS: PO 25 to 50 mg 1 to 3 times/day.

 Interactions

Guanethidine: May decrease hypotensive effect. MAOIs, furazolidone: May cause hypertensive crisis and intracranial hemorrhage. Selective serotonin reuptake inhibitors (eg, fluoxetine): Sympathomimetic effects of benzphetamine may be increased; increased risk of “serotonin syndrome.”

 Lab Test Interferences None well documented.

 Adverse Reactions

CARDIOVASCULAR: Palpitations; tachycardia; arrhythmias; hypertension; hypotension; chest pain. CNS: Hypersensitivity; dizziness; insomnia; euphoria; tremor; headache; restlessness; overstimulation; nervousness; anxiety; agitation. DERMATOLOGIC: Urticaria; rash; erythema; hair loss. EENT: Mydriasis; blurred vision; unpleasant taste. GI: Dry mouth; nausea; diarrhea; constipation; stomach pain. GU: Dysuria; urinary frequency; impotence; menstrual disturbances. HEMATOLOGIC: Bone marrow depression; agranulocytosis; leukopenia. OTHER: Excessive sweating; flushing; myalgia; gynecomastia.

 Precautions

Pregnancy: Category X. Lactation: Undetermined. Children: Not recommended for children < 12 yr. Drug dependence: High potential for dependence and abuse; tolerance may occur. Tartrazine sensitivity: Some products contain tartrazine, which may cause allergic-type reactions in susceptible individuals.

PATIENT CARE CONSIDERATIONS


 Administration/Storage

  • Administer mid-morning or mid-afternoon. Anorexiant effects occur within 1 to 2 hr and last up to 4 hr.
  • Administer last dose several hours before bedtime.
  • Store at room temperature in tightly closed, light-resistant container.

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note cardiovascular disease, hypertension, glaucoma, and history of drug or alcohol abuse.
  • Monitor renal function.
  • Take vital signs and auscultate heart and lungs before administration.
  • Assess mental status. Depressed patients are more likely to misuse drug to induce euphoria and mood elevation.
  • If hypertension, dysrhythmias, marked agitation, restlessness, depression, or other adverse effects occur, withhold medication and notify health care provider.
  • For best results, administer medication concurrently with a program to improve eating habits, increase motivation, and improve self-image.
OVERDOSAGE: SIGNS & SYMPTOMS
  Restlessness, tremor, rapid respirations, tachypnea, dizziness, confusion, mood changes, panic states, dysrhythmias, palpitations, and hypertension or hypotension

 Patient/Family Education

  • Caution patient that this medication must not be taken during pregnancy or when pregnancy is possible. Advise patient to use reliable form of birth control while taking this drug.
  • Remind patient to take medication on empty stomach (1 hr before meal or 2 hr after meal).
  • Instruct patient to avoid taking medication within 6 hr of bedtime because it may cause insomnia.
  • Explain that anorexiant effects are temporary and tolerance to medication and dependence can occur.
  • Instruct patient to notify health care provider immediately if the following symptoms occur: chest pain, palpitations, nervousness, or dizziness.
  • Warn patient not to drive or perform tasks that require mental alertness if dizziness or blurred vision occurs. Notify health care provider of these disturbances.
  • Tell patient to report excessive dryness of mouth, constipation, or prolonged insomnia because dosage may need to be adjusted.
  • Inform patient that weight reduction requires strict adherence to dietary restrictions.

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Drugs Class ::

(benz-FET-uh-meen HIGH-droe-KLOR-ide)
Didrex
Tablets: 25 mg, 50 mg
Class: CNS stimulant/Anorexiant

Indications for Drugs ::

 Indications Short-term (few weeks) adjunct to diet plan to reduce weight.

Drug Dose ::

 Route/Dosage

ADULTS: PO 25 to 50 mg 1 to 3 times/day.

Contraindication ::

 Contraindications Hypersensitivity to sympathomimetic amines; pregnancy; advanced arteriosclerosis; symptomatic cardiovascular disease; moderate to severe hypertension; hyperthyroidism; glaucoma; agitated states; history of drug abuse; during or within 14 days of MAOI use; coadministration with other CNS stimulants.

Drug Precautions ::

 Precautions

Pregnancy: Category X. Lactation: Undetermined. Children: Not recommended for children < 12 yr. Drug dependence: High potential for dependence and abuse; tolerance may occur. Tartrazine sensitivity: Some products contain tartrazine, which may cause allergic-type reactions in susceptible individuals.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CARDIOVASCULAR: Palpitations; tachycardia; arrhythmias; hypertension; hypotension; chest pain. CNS: Hypersensitivity; dizziness; insomnia; euphoria; tremor; headache; restlessness; overstimulation; nervousness; anxiety; agitation. DERMATOLOGIC: Urticaria; rash; erythema; hair loss. EENT: Mydriasis; blurred vision; unpleasant taste. GI: Dry mouth; nausea; diarrhea; constipation; stomach pain. GU: Dysuria; urinary frequency; impotence; menstrual disturbances. HEMATOLOGIC: Bone marrow depression; agranulocytosis; leukopenia. OTHER: Excessive sweating; flushing; myalgia; gynecomastia.

Drug Mode of Action ::  

(benz-FET-uh-meen HIGH-droe-KLOR-ide)
Didrex
Tablets: 25 mg, 50 mg
Class: CNS stimulant/Anorexiant

Drug Interactions ::

 Interactions

Guanethidine: May decrease hypotensive effect. MAOIs, furazolidone: May cause hypertensive crisis and intracranial hemorrhage. Selective serotonin reuptake inhibitors (eg, fluoxetine): Sympathomimetic effects of benzphetamine may be increased; increased risk of “serotonin syndrome.”

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note cardiovascular disease, hypertension, glaucoma, and history of drug or alcohol abuse.
  • Monitor renal function.
  • Take vital signs and auscultate heart and lungs before administration.
  • Assess mental status. Depressed patients are more likely to misuse drug to induce euphoria and mood elevation.
  • If hypertension, dysrhythmias, marked agitation, restlessness, depression, or other adverse effects occur, withhold medication and notify health care provider.
  • For best results, administer medication concurrently with a program to improve eating habits, increase motivation, and improve self-image.
OVERDOSAGE: SIGNS & SYMPTOMS
  Restlessness, tremor, rapid respirations, tachypnea, dizziness, confusion, mood changes, panic states, dysrhythmias, palpitations, and hypertension or hypotension

Drug Storage/Management ::

 Administration/Storage

  • Administer mid-morning or mid-afternoon. Anorexiant effects occur within 1 to 2 hr and last up to 4 hr.
  • Administer last dose several hours before bedtime.
  • Store at room temperature in tightly closed, light-resistant container.

Drug Notes ::

 Patient/Family Education

  • Caution patient that this medication must not be taken during pregnancy or when pregnancy is possible. Advise patient to use reliable form of birth control while taking this drug.
  • Remind patient to take medication on empty stomach (1 hr before meal or 2 hr after meal).
  • Instruct patient to avoid taking medication within 6 hr of bedtime because it may cause insomnia.
  • Explain that anorexiant effects are temporary and tolerance to medication and dependence can occur.
  • Instruct patient to notify health care provider immediately if the following symptoms occur: chest pain, palpitations, nervousness, or dizziness.
  • Warn patient not to drive or perform tasks that require mental alertness if dizziness or blurred vision occurs. Notify health care provider of these disturbances.
  • Tell patient to report excessive dryness of mouth, constipation, or prolonged insomnia because dosage may need to be adjusted.
  • Inform patient that weight reduction requires strict adherence to dietary restrictions.

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