Details About Generic Salt ::  Biperide

Main Medicine Class:: Antiparkinson,Anticholinergic   

(by-PURR-ih-den)
Akineton
Class: Antiparkinson/Anticholinergic

 

Drugs Class ::

 Action Thought to act by competitively antagonizing acetylcholine receptors in corpus striatum to restore neuromuscular balance.

Indications for Drugs ::

 Indications Treatment of all forms of parkinsonism; control of extrapyramidal disorders secondary to neuroleptic drug therapy.

Drug Dose ::

 Route/Dosage

Parkinsonism

ADULTS: PO 2 mg tid to qid to maximum of 16 mg/day. Dosage must be individualized.

Drug-Induced Extrapyramidal Disorders

ADULTS: PO 2 mg qd to tid. IM/IV 2 mg repeated q 30 min until symptoms resolve, but not more than 4 consecutive doses (or 8 mg) per day.

Contraindication ::

 Contraindications Narrow angle glaucoma; bowel obstruction; megacolon.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly: Patients > 60 yr may have increased side effects; dosage reduction and observation may be needed. Heat illness: Fatal hyperthermia has occurred. Use with caution during hot weather. Ophthalmic: Narrow-angle glaucoma may occur. Special risk patients: Use with caution in patients with glaucoma, prostatic hypertrophy, epilepsy, cardiac arrhythmias, hypertension, hypotension, tendency toward urinary retention, liver or kidney disorders, obstructive disease of GI or GU tract, tachycardia or those who are taking other drugs with anticholinergic activity.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Mild transient orthostatic hypotension; bradycardia; tachycardia. EENT: Blurred vision; narrow-angle glaucoma; pupillary dilation. CNS: Drowsiness; euphoria; disorientation; agitation; memory loss; disturbed behavior. DERM: Skin rash. GI: Dry mouth; constipation; GI irritation. GU: Urinary retention. OTHER: Hyperthermia; heat stroke.

Drug Mode of Action ::  

 Action Thought to act by competitively antagonizing acetylcholine receptors in corpus striatum to restore neuromuscular balance.

Drug Interactions ::

 Interactions

Amantadine: May increase anticholinergic side effects. Digoxin: May increase digoxin serum levels, especially with slow-dissolution oral digoxin tablets. Haloperidol: May worsen schizophrenic symptoms; may decrease haloperidol serum levels; tardive dyskinesia may develop. May decrease action of phenothiazines. May increase incidence of anticholinergic side effects.

Drug Assesment ::

 Assessment/Interventions

  • Take patient history, including drug history and any known allergies. Note glaucoma, urinary retention, prostatic hypertrophy or constipation.
  • Monitor vital signs and I&O routinely for anticholinergic side effects (hypotension and urinary retention).
  • Monitor patient for reduction of rigidity and decrease in tremors during therapy.
  • Monitor frequency and consistency of bowel movement. Patient may need stool softeners or laxatives.
OVERDOSAGE: SIGNS & SYMPTOMS
  Characterized by adverse reactions. Also: Circulatory collapse, cardiac arrest, respiratory depression or arrest, CNS depression preceded or followed by stimulation, intensification of mental symptoms or toxic psychosis in mentally ill patients treated with neuroleptic drugs (eg, phenothiazines), shock, coma, stupor, seizures, convulsions, ataxia, anxiety, incoherence, hyperactivity, combativeness, anhidrosis, hyperpyrexia, fever, hot/dry/flushed skin, dry mucous membranes, dysphagia, foul-smelling breath, decreased bowel sounds, dilated and sluggish pupils

Drug Storage/Management ::

 Administration/Storage

  • When given PO, administer with or after meals to prevent GI irritation.
  • If patient has difficulty swallowing, tablet may be crushed.
  • May be given IM or IV in acute dystonic reactions. When given IV, have patient remain recumbent during administration and for 15 min afterward.
  • Store in dry place in tightly closed light-resistant container.

Drug Notes ::

 Patient/Family Education

  • Explain that doses will be tapered gradually before stopping to avoid withdrawal reaction.
  • Advise patient that increasing fluid intake will help decrease dry mouth and constipation.
  • Instruct patient to pay particular attention to dental hygiene because of problems associated with decreased salivation (eg, increased risk of caries).
  • Tell patient that stool softeners may be used if constipation occurs. Small doses of milk of magnesia may be helpful.
  • Warn patient to drink plenty of fluids and take precautions against hyperthermia in hot weather.
  • Instruct patient to obtain periodic eye exams during long-term treatment to monitor for glaucoma.
  • Advise patient that wearing sunglasses outdoors will help to minimize photophobia.
  • Tell patient that vision may be blurry during first 2 to 3 wk of treatment.
  • Instruct patient to take sips of water frequently, suck on ice chips or sugarless hard candy or chew sugarless gum if dry mouth occurs.
  • Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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