Details About Generic Salt ::  Cefixime

Main Medicine Class::    

(SEFF-IKS-eem)
Suprax
Class: Antibiotic/cephalosporin

 

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of uncomplicated urinary tract infections, otitis media, pharyngitis and tonsillitis, acute bronchitis, exacerbation of chronic bronchitis, and uncomplicated gonorrhea due to susceptible strains of specific microorganisms.

Drug Dose ::

 Route/Dosage

Infection

ADULTS & CHILDREN > 12 YR OR > 50 KG: PO 400 mg/day as single dose or two divided doses q 12 hr. CHILDREN 6 MO-12 YR: PO 8 mg/kg/day as single dose or two divided doses q 12 hr.

Uncomplicated Gonorrhea

ADULTS: PO 400 mg or 800 mg as single dose.

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: In infants, consider benefits relative to risks. Safety and efficacy in children < 6 mo not established. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Should be considered possibility in patients in whom diarrhea develops. Renal impairment: Use drug with caution in patients with renal impairment. Dosage adjustment based on renal function may be required. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

GI: Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis. GU: Pyuria; dysuria; renal dysfunction; reversible interstitial nephritis; hematuria; toxic nephropathy. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. HEPA: Hepatic dysfunction; abnormal liver function test results. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme and toxic epidermal necrolysis; serum sickness-like reactions (eg, skin rash, polyarthritis, arthralgia, fever); candidal overgrowth.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Probenecid: Inhibition of renal excretion of cefixime.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note renal impairment and allergy to cephalosporins and penicillins.
  • Obtain specimens for culture and sensitivity before beginning therapy and periodically during treatment.
  • Monitor renal function carefully during treatment.
  • Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
  • Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
  • Assess for symptoms of superinfection, such as vaginitis or stomatitis.
  • Assess for severe diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
OVERDOSAGE: SIGNS & SYMPTOMS
  Seizures

Drug Storage/Management ::

 Administration/Storage

  • Administer with food or milk if GI upset occurs.
  • Suspension should be used in treatment of otitis media because it results in higher peak blood concentrations.
  • At room temperature oral suspension will remain stable for up to 14 days. Do not freeze. Shake well before use.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to complete full course of therapy.
  • Remind patient to check body temperature daily. If fever persists more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
  • Advise patient to maintain normal fluid intake while using this medication.
  • Advise diabetic patient to use enzyme-based test (eg, Clinistix, Testape) for monitoring urine glucose because drug may give false results with other tests.
  • Instruct patient to report these symptoms to physician: nausea, vomiting, diarrhea, skin rash, hives, muscle or joint pain.
  • Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
  • Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
  • Instruct patient to seek emergency care immediately if wheezing or difficulty in breathing occurs.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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