Details About Generic Salt ::  Cefonici

Main Medicine Class::    

(seh-FAHN-ih-SID SO-dee-uhm)
Monocid
Class: Antibiotic/cephalosporin

 

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections of lower respiratory tract, urinary tract, skin and skin structures, bone and joint; treatment of septicemia due to susceptible microorganisms; pre-operative prophylaxis.

Drug Dose ::

 Route/Dosage

Infections

ADULTS: IV/IM 1–2 g/24 hr.

Preoperative Prophylaxis

ADULTS: IV/IM 1 g 1 hr prior to surgical procedure; daily doses may be repeated for 2 additional days; may be given to patients undergoing prosthetic arthroplasty or open heart surgery.

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy in children not established. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillinsensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Should be considered in patients in whom diarrhea develops. Renal impairment: Use drug with caution. Dosage adjustment based on renal function may be required. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

GI: Diarrhea; pseudomembranous colitis. GU: Renal dysfunction; pyuria; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. HEPA: Hepatic dysfunction; abnormal liver function test results. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness—like reactions (eg, skin rashes, polyarthritis; arthralgia, fever); phlebitis, thrombophlebitis and pain at injection site.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Aminoglycosides: May increase risk of nephrotoxicity. Probenecid: Inhibition of renal excretion of cefonicid.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note allergy to cephalosporins and penicillins.
  • Obtain specimen for culture and sensitivity before beginning therapy and periodically during treatment.
  • Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
  • Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
  • Assess for signs of superinfection, such as vaginitis or stomatitis.
  • Assess for diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
  • Monitor IV site for infiltration, infection, and thrombophlebitis.
OVERDOSAGE: SIGNS & SYMPTOMS
  Seizures

Drug Storage/Management ::

 Administration/Storage

  • For IM administration, inject deeply within body of large muscle (eg, gluteus muscle). When giving 2 g IM doses once daily, divide dose in ½ and give in different large muscle masses.
  • For direct bolus injection, administer reconstituted solution slowly over 3–5 min.
  • For IV infusion, administer reconstituted solution over 20–30 min.
  • After reconstitution or dilution, solution is stable for 24 hr at room temperature or 72 hr if refrigerated. Do not administer if solution is cloudy or precipitate is present.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to check body temperature daily. If fever persists for more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
  • Advise patient to maintain normal fluid intake while using this medication.
  • Advise patient not to drink alcoholic beverages or take alcohol-containing medications while taking this medication and for several days after discontinuing it.
  • Inform diabetic patient to use enzyme-based tests (eg, Clinistix, Testape) for monitoring urine glucose because drug may give false results with other tests.
  • Instruct patient to report these symptoms to physician: nausea, vomiting, diarrhea, skin rash, hives, sore throat, bruising, bleeding, muscle or joint pain.
  • Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
  • Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
  • Instruct patient to seek emergency care if wheezing or difficulty in breathing occurs.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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