Details About Generic Salt ::  Cephapir

Main Medicine Class:: Antibiotic,cephalosporin   

(SEFF-uh-PIE-rin SO-dee-uhm)
Cefadyl
Class: Antibiotic/cephalosporin

 

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections of respiratory tract, urinary tract, skin and skin structures; treatment of endocarditis, osteomyelitis, septicemia due to susceptible strains of specific microorganisms; perioperative prophylaxis.

Drug Dose ::

 Route/Dosage

Infection

ADULTS: IV/IM 500 mg-2 g q 4–6 hr. (serious or life-threatening infections: up to 12 g/day). CHILDREN > 3 MO: IV/IM 40–80 mg/kg/day in 4 equally divided doses.

Perioperative Prophylaxis

ADULTS: IV/IM 1–2 g ½–1 hr before surgery then 1–2 g q 6 hr for 24 hr.

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: In infants, consider benefits relative to risks. Cephalosporins may accumulate in neonates. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Should be considered in patients in whom diarrhea develops. Renal impairment: Use drug with caution in patients with renal impairment. Dosage adjustment based on renal function may be required. superinfection: May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

GI: Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis. GU: Pyuria; renal dysfunction; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. HEPA: Hepatic dysfunction; abnormal liver function test results. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness–like reactions (eg, skin rashes, polyarthritis, arthralgia, fever); phlebitis, thrombophlebitis and pain at injection site.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Aminoglycosides: Increased risk of nephrotoxicity. Probenecid: Inhibition of renal excretion of cephapirin.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note renal impairment and allergy to cephalosporins or penicillins.
  • Obtain specimens for culture and sensitivity before beginning therapy and periodically during treatment.
  • Monitor renal function carefully during treatment.
  • Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
  • Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
  • Assess for signs of superinfection, such as vaginitis or stomatitis.
  • Assess for diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
  • Monitor IV site for signs of infiltration, infection and thrombophlebitis.
OVERDOSAGE: SIGNS & SYMPTOMS
  Seizures

Drug Storage/Management ::

 Administration/Storage

  • Reconstituted solution should be light yellow to amber. Do not administer if solution is cloudy or precipitate is present.
  • When giving by IM route, inject deeply into large muscle (eg, upper outer quadrant of gluteus muscle or lateral thigh); massage well. Rotate injection sites.
  • When giving by IV route, administer slowly over 3–5 min or further dilute with 50–100 ml D5W or 0.9% Sodium Chloride and infuse over 30 min. Change IV site q 48–72 hr.
  • Reconstituted solution is stable for 24 hr at room temperature, 10 days when refrigerated and 14 days if frozen immediately after reconstitution.
  • Thaw frozen solution completely at room temperature or under refrigeration before use. Do not force thaw. Do not refreeze.

Drug Notes ::

 Patient/Family Education

  • Remind patient to check body temperature daily. If fever persists for more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
  • Advise patient to maintain normal fluid intake while using this medication.
  • Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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