Details About Generic Salt ::  Diphthe1

Main Medicine Class:: Vaccine, inactivated bacteria   

(diff-THEER-ee-uh/TET-ah-nus toxoids/whole cell per-TUSS-iss vaccine)

DTwP, Tri-Immunol

Class: Vaccine, inactivated bacteria

 

Drugs Class ::

 Action Diphtheria and tetanus toxoids induce antibodies against toxins made by Corynebacterium diphtheriae and Clostridium tetani. Pertussis vaccine protects against Bordetella pertussis.

Indications for Drugs ::

 Indications Induction of active immunity against diphtheria, tetanus and pertussis for children.

Drug Dose ::

 Route/Dosage

Children: IM 0.5 ml at 2 mo, 4 mo, 6 mo, and 12 to 18 mo and 4 to 6 yr.

Contraindication ::

 Contraindications Children who recovered from culture-confirmed pertussis; history of serious adverse reactions to previous dose of pertussis-containing vaccine; immediate anaphylactic reaction or encephalopathy occurring within 7 days after any DTP vaccination. (If contraindication to pertussis-vaccine component occurs, substitute diphtheria and tetanus toxoids for pediatric use [DT] for each of the remaining doses.)

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Contraindicated in children < 6 wk or > 7 yr; do not reduce or divide dose for infants or children. Children with thrombocytopenia or any coagulation disorder in whom IM injection may be contraindicated: Give vaccine with caution. Febrile illness or acute infection: Defer immunization during course of illness. Minor respiratory illness such as mild upper respiratory infection is not usually reason to defer immunization. Hypersensitivity: Review patient history for possible sensitivity. Have epinephrine 1:1000 immediately available. Infections: Do not use DTwP for treatment of actual infection.

PATIENT CARE CONSIDERATIONS

Drug Side Effects ::

 Adverse Reactions

DERM: Rash. GI: Diarrhea or loose stools; vomiting. RESP: Upper respiratory infection or rhinitis. OTHER: Fever; irritability. Although very rare, causal association exists between DTwP and acute encephalopathy, shock and unusual shocklike state, anaphylaxis and protracted, inconsolable crying; pain, redness and induration at injection site.

Drug Mode of Action ::  

 Action Diphtheria and tetanus toxoids induce antibodies against toxins made by Corynebacterium diphtheriae and Clostridium tetani. Pertussis vaccine protects against Bordetella pertussis.

Drug Interactions ::

 Interactions

Anticoagulants: Give DTwP with caution to persons on anticoagulant therapy. Influenza vaccine: To attribute causality of adverse reactions, do not give influenza vaccine within 3 days of pertussis vaccination. Immunosuppressants: May reduce efficacy of vaccine. If possible, deter giving vaccine until immunocompetency returns.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Review patient’s medical history for conditions that would contraindicate DTwP vaccine (children who have recovered from culture-confirmed pertussis, history of serious adverse reactions to previous dose of DTwP, hypersensitivity to any component of vaccine, anaphylactic reaction or encephalopathy occurring within 7 days after any DTP vaccination).
• Take child’s temperature to determine if infection is present.
• Defer immunization during course of any febrile illness or acute infection. Minor respiratory illness such as mild upper respiratory infection is not usually reason to defer immunization.
• Give any DTP injection with caution to children with thrombocytopenia or any coagulation disorder in which IM injection may be contraindicated.
• When child returns for next dose in series of either pertussis or any DTP vaccine, question child’s parent or guardian about serious side effects with previous dose. If any side effects that contraindicate additional pertussis vaccine are noted, consult with child’s pediatrician and continue childhood immunization with bivalent diphtheria and tetanus toxoids (DT) if recommended.
• There are no data on whether prophylactic use of antipyretic drugs (eg, acetaminophen) can decrease risk of febrile convulsions. Acetaminophen may reduce incidence of postvaccination fever. Immunization Practices Advisory Committee and American Academy of Pediatrics suggest administering appropriate dose of acetaminophen (based on age) at the time of vaccination and q 4 to 6 hr to children at higher risk for seizures than general population (ie, children with personal or family history of seizures).

Drug Storage/Management ::

 Administration/Storage

• Administer drug by IM route only. Anterolateral aspect of thigh or deltoid muscle of upper arm is preferred. Do not inject in gluteal area or other areas with major nerve trunk.
• May administer vaccine with trivalent oral polio, injectable polio, Haemophilus b, hepatitis B, varicella, and measles, mumps and rubella virus vaccines.
• Always record the manufacturer’s name and vaccine lot number in child’s permanent record file, along with date of administration, name, address and title of person administering vaccine.
• Shake vial well to ensure uniform suspension before withdrawing dose. If clumps remain after vigorous agitation, discard vial and contents. Rotate vial in palm to bring contents to room temperature before administration.
• Refrigerate vials; do not freeze. Discard frozen vaccine.

Drug Notes ::

 Patient/Family Education

• Inform parent of name, action, administration and side effects of DTwP.
• Provide parent with immunization history record and record this immunization in patient’s medical record.
• Instruct parent to give acetaminophen for fever and local pain.
• If patient will require further doses, review immunization schedule with parent and arrange for return visits as necessary.
• Advise parent to check with local school board; some school systems require that children receive complete series of vaccinations before entrance into kindergarten or elementary school.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.