Details About Generic Salt ::  Griseofu

Main Medicine Class:: Anti-infective,Antifungal   

(griss-ee-oh-FULL-vin)
Microsize
Fulvicin U/F, Grifulvin V, Grisactin 500, Grisactin 250,  Grisovin-FP
Ultrasize
Fulvicin P/G, Gris-PEG, Grisactin Ultra
Class: Anti-infective/Antifungal

 

Drugs Class ::

 Action Deposited preferentially into infected skin, which gradually sloughs off and is replaced by noninfected tissue; binds tightly to new keratin, which becomes highly resistant to fungal invasions.

Indications for Drugs ::

 Indications Treatment of ringworm infections of skin, hair, and nails caused by susceptible fungi.

Drug Dose ::

 Route/Dosage

ADULTS: PO 500 to 1000 mg microsize (330 to 750 mg ultramicrosize) in single or divided doses. May need to give for several weeks. CHILDREN: PO 11 mg microsize kg/day (125 to 500 mg) or 7.3 mg ultramicrosize/kg/day (82.5 to 330 mg).

Contraindication ::

 Contraindications Porphyria; hepatic disease.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Hypersensitivity: Drug may need to be discontinued. Also, penicillin cross-sensitivity is possible, although some penicillin-sensitive patients have used without difficulty. Lupus: May exacerbate lupus or lupus-like syndrome.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Headache; fatigue; dizziness; insomnia; confusion; paresthesias. DERM: Rash; urticaria. EENT: Oral thrush. GI: Nausea; vomiting; epigastric distress; diarrhea; GI bleeding. GU: Proteinuria. HEMA: Leukopenia; granulocytopenia. HEPA: Hepatic toxicity. META: Interferes with porphyrin metabolism. OTHER: Angioneurotic edema.

Drug Mode of Action ::  

 Action Deposited preferentially into infected skin, which gradually sloughs off and is replaced by noninfected tissue; binds tightly to new keratin, which becomes highly resistant to fungal invasions.

Drug Interactions ::

 Interactions

Alcohol: Effects of alcohol may be potentiated with tachycardia and flushing. Anticoagulants: Anticoagulant effect may be decreased. Barbiturates: May depress griseofulvin serum levels. Oral contraceptives: May cause loss of contraceptive effectiveness.

Drug Assesment ::

 Assessment/Interventions

  • Evaluate skin condition prior to and throughout therapy.
  • Institute general supportive measures to maintain skin integrity.
  • Observe for signs of infection or reinfection.
  • Institute safety precautions if dizziness or other neurologic alterations occur.

Drug Storage/Management ::

 Administration/Storage

  • Administer with or after meals, particularly with fatty foods if not contraindicated.
  • Generally administered in conjunction with topical agent.
  • Do not interchange griseofulvin microsize with ultramicrosize because dosage is different.
  • Store at room temperature in tightly closed containers.

Drug Notes ::

 Patient/Family Education

  • Advise patient to inspect skin for signs of improvement of infection or re-infection.
  • Explain importance of good hygiene, particularly to affected areas.
  • Inform patient that beneficial effects of drug may not be observable for weeks to months.
  • Emphasize importance of continued follow-up examinations.
  • Instruct patient to report these symptoms to health care provider: Fever, sore throat, or skin rash.
  • Caution patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Advise patient that drug may cause dizziness and to use caution while driving or performing other tasks requiring mental alertness.
  • Caution patient to avoid exposure to sunlight and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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