Details About Generic Salt ::  Loratadi

Main Medicine Class:: Antihistamine   

(lore-AT-uh-DEEN)
Claritin
Tablets: 10 mg, Tablets, rapidly disintegrating: 10 mg, Syrup: 1 mg/mL
Class: Antihistamine

 

Drugs Class ::

 Action Competitively antagonizes histamine at the H1-receptor site.

Indications for Drugs ::

 Indications Symptomatic relief (nasal and nonnasal) of symptoms associated with seasonal allergic rhinitis; treatment of chronic idiopathic urticaria.

Drug Dose ::

 Route/Dosage

ADULTS and CHILDREN ³ 6 yr: PO 10 mg once daily.

CHILDREN 2 to 5 yr: PO 5 mg once daily.

Hepatic Impairment

ADULTS and CHILDREN ³ 6 yr: PO Start with 10 mg every other day.

CHILDREN 2 to 5 yr: PO Start with 5 mg every other day.

Renal Impairment (GFR < 30 mL/min):

ADULTS and CHILDREN ³ 6 yr: PO Start with 10 mg every other day.

CHILDREN 2 to 5 yr: PO Start with 5 mg every other day.

Contraindication ::

 Contraindications Hypersensitivity to antihistamines; use in nursing women.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established in children < 12 yr. Hepatic Impairment: Use drug with caution in patients with hepatic impairment. Hypersensitivity: Hypersensitivity may occur.

PATIENT CARE CONSIDERATIONS

Drug Side Effects ::

 Adverse Reactions

CARDIOVASCULAR: Hypotension; hypertension; palpitations; tachycardia. CNS: Hyperkinesia; paresthesia; dizziness; migraine; tremor; vertigo; headache; somnolence; fatigue. DERMATOLOGIC: Dermatitis; dry hair; dry skin; urticaria; rash; pruritus; purpura; photosensitivity. EENT: Conjunctivitis; blurred vision; earache; eye pain; blepharospasm; dysphonia; altered taste. GI: Anorexia; increased appetite and weight gain; nausea; vomiting; diarrhea; constipation; flatulence; gastritis; dyspepsia; dry mouth. GU: Urinary discoloration; altered micturation; menstrual irregularities. RESPIRATORY: Nasal dryness; pharyngitis; epistaxis; nasal congestion; dyspnea; coughing; rhinitis; hemoptysis; sinusitis; sneezing; bronchospasm; bronchitis; laryngitis. OTHER: Breast pain; arthralgia; myalgia.

Drug Mode of Action ::  

 Action Competitively antagonizes histamine at the H1-receptor site.

Drug Interactions ::

 Interactions

Alcohol, CNS depressants: Additive CNS depressant effects.

Azole Antifungals (eg, ketoconazole, itraconazole): Use of these agents with similar antihistamines has resulted in serious cardiac toxicity, including death.

Food: May increase absorption of loratadine.

MAO Inhibitors: Concomitant use may prolong and intensify anticholinergic effects of loratadine and may result in hypotensive episodes.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies, especially to antihistamines.
  • Obtain baseline BP, respirations, and pulse before beginning therapy.
  • Monitor closely for signs of hypersensitivity if patient has history of allergic reactions to other antihistamines.
  • Observe for dizziness, excessive sedation, syncope, confusion, and hypotension, especially in elderly patients.
OVERDOSAGE: SIGNS & SYMPTOMS
  Somnolence, tachycardia, headache

Drug Storage/Management ::

 Administration/Storage

  • Administer on empty stomach 1 hr before or 2 hr after eating.
  • Store at room temperature.

Drug Notes ::

 Patient/Family Education

  • Warn patient not to increase dose to obtain quicker relief of symptoms.
  • If patient is to have allergy skin testing, advise to avoid taking medication for 4 days before test.
  • Tell patient that drug may be used alone for symptoms of sneezing and runny nose with slight nasal congestion.
  • Advise patient not to take any otc medications without consulting health care provider.
  • Instruct patient to maintain fluid intake of 1½ to 2 quarts/day to decrease viscosity of secretions.
  • Caution patient to avoid exposure to sunlight and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants (eg, sedatives, hypnotics, tranquilizers).
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness until response to medication is known.
  • Explain that rapidly disintegrating tablet will disintegrate on the tongue and may be administered with or without water.

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