Details About Generic Salt ::  Meropene

Main Medicine Class:: Anti-infective,carbapenem   

(mare-oh-PEN-em)
Merrem
Class: Anti-infective/carbapenem

 

Drugs Class ::

 Action Inhibits cell wall synthesis.

Indications for Drugs ::

 Indications Treatment of intra-abdominal infections in adults and children ³ mo and meningitis in children ³ 3 mo when caused by susceptible microorganisms.

Drug Dose ::

 Route/Dosage

Intra-abdominal infections

ADULTS: IV 1 g IV q 8 hr. CHILDREN ³ 3 MO: IV 20 mg/kg q 8 hr. Maximum dose: 2 g every 8 hr.

Meningitis

CHILDREN ³ 3 MO: IV 40 mg/kg q 8 hr. Maximum dose: 2 g every 8 hr.

Contraindication ::

 Contraindications Hypersensitivity to any component of this product or to other drugs in the same class or in patients who have demonstrated anaphylactic reactions to B-lactarus.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy in children < 3 months not established. CNS: Seizures and other CNS adverse events have occurred. Use with caution in patients with CNS disorders, meningitis or renal dysfunction. Renal function impairment: Reduced clearance may occur. Adjust dose downward accordingly in patients with creatinine clearance < 50 ml/min. Refer to manufacturer’s package insert for dose calculations. Thrombocytopenia, without bleeding, has been observed. Hypersensitivity: Administer drug with caution to penicillin-sensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Consider possibility in patients with diarrhea. Superinfection: May result in bacterial or fungal overgrowth of non-susceptible organisms.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

RESP: Apnea. CNS: Headache. DERM: Rash; pruritis. EENT: Stomatitis. GI: Diarrhea; nausea; vomiting; constipation. GU: Vaginitis. OTHER: Injection site reactions (pain, edema, inflammation).

Drug Mode of Action ::  

 Action Inhibits cell wall synthesis.

Drug Interactions ::

 Interactions

Probenecid: Inhibits renal excretion of meropenem. Coadministration is not recommended. INCOMPATIBILITIES: Do not physically mix with solutions containing other drugs.

Drug Assesment ::

 Assessment/Interventions

  • Obtain complete patient history, including drug history and any known allergies, especially to penicillin and B-lactam antibiotics.
  • Notify physician if signs of superinfection (eg, vaginitis, stomatitis) or pseudomembranous colitis (eg, diarrhea with blood or pus) occurs.
  • Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal edema). Have resuscitation equipment available.
  • If seizures occur, withhold drug, institute safety measures and notify physician.
  • If culture and sensitivity is ordered, obtain specimen(s) rior to first dose.
  • Withhold drug and notify physician if any of the following occur: fever, rash, hives.
  • Monitor vital signs, sputum, urine, stool and WBC at beginning of and throughout therapy.
OVERDOSAGE: SIGNS & SYMPTOMS
  Seizures

Drug Storage/Management ::

 Administration/Storage

  • For IV administration only. Do not use solution if discolored or if particulate matter is seen.
  • For IV bolus administration, reconstitute with sterile water for injection. Shake to dissolve and let stand until clear. May administer over 3–5 min.
  • For IV infusion, reconstitute infusion vial with compatible infusion fluid or use ADD-Vantage flexible diluent container for ADD-Vantage vial following instructions. Can administer over 15–30 min.
  • Store dry powder for reconstitution at controlled room temperature.
  • Stability of reconstituted meropenem is dependent on diluent and container (eg, syringe, infusion vial, minibag, ADD-Vantage diluent bag). Refer to manufacturer’s package insert for guidelines.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to report to physician or nurse itching, rash, hives, difficulty breathing, diarrhea, black “furry” tongue, loose, foul-smelling stool or vaginal itching or discharge.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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