Details About Generic Salt ::  Niacin

Main Medicine Class:: Vitamin,Antihyperlipidemic   

(NYE-uh-sin)
Niacor, Nicotinex, Slo-Niacin
Class: Vitamin/Antihyperlipidemic

 

Drugs Class ::

 Action Necessary for lipid metabolism, tissue respiration and glycogenolysis. At pharmacologic doses, it reduces total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. Also causes peripheral vasodilation, especially cutaneous vessels.

Indications for Drugs ::

 Indications Prevention and treatment of niacin deficiency or pellagra; treatment of hyperlipidemia (types IV and V); adjunct to diet for the reduction of elevated total and LDL levels in patients with primary hypercholesterolemia when the response to diet and other nonpharmacologic measures alone has been adequate. unlabeled use(s): Treatment of peripheral vascular disease, vascular spasm, migraine, headache, Meniere disease.

Drug Dose ::

 Route/Dosage

Pellagra

ADULTS: PO Up to 500 mg daily in divided doses. Slow IV/SC/IM When oral route is not possible.

Dietary Supplementation

ADULTS: PO RDA is 15 to 20 mg/day for adult males and 13 to 15 mg/day for adult females. Increase niacin to 17 to 20 mg/day during pregnancy and lactation. CHILDREN: PO RDA is 5 to 20 mg/day.

Hyperlipidemia

ADULTS: PO 1 to 2 g tid, with or after meals. Titrate doses gradually. Lower doses may be effective if using sustained-release products.

Contraindication ::

 Contraindications Significant liver disease; active peptic ulcer; severe hypotension; arterial hemorrhaging.

Drug Precautions ::

 Precautions

Pregnancy: Category A. (Category C if used in doses above RDA.) Lactation: Actively excreted in breast milk. Children: Safety and efficacy not established for doses exceeding nutritional requirements. Extended-release preparations not recommended for children. Special-risk patients: Use drug with caution when administering to patients with gallbladder disease, history of jaundice, diabetes mellitus, gout, peptic ulcer, or allergy. Also, patients allergic to aspirin may be allergic to this product. Flushing: Commonly appears with oral therapy. Aspirin (325 mg) 30 min to 1 hr before niacin may decrease flushing. Long-acting dosage form: Increases risk of jaundice and hepatitis. Avoid use if possible. Heart disease: People who have recurrent chest pain (angina) or who recently suffered a heart attack should take niacin only under the supervision of a physician. Tartrazine sensitivity: Products containing FD&C yellow #5 may cause asthma in susceptible patients.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Hypotension; tachycardia. CNS: Dizziness; syncope; headache. DERM: Flushing; pruritus; burning or tingling sensation; rash; hyperpigmentation (acanthosis nigricans); dry skin. EENT: Blurred vision; xerostomia. GI: Nausea; bloating; flatulence; hunger; vomiting; heartburn; diarrhea; activation of peptic ulcer; abdominal pain; dyspepsia. HEPA: Jaundice; liver damage; abnormal liver function test results. OTHER: Hyperuricemia; hyperglycemia; decreased glucose tolerance test results; toxic amblyopia; atrial fibrillation and other cardiac arrhythmias; cystoid macular edema; orthostasis.

Drug Mode of Action ::  

 Action Necessary for lipid metabolism, tissue respiration and glycogenolysis. At pharmacologic doses, it reduces total cholesterol, LDL cholesterol, and triglycerides while increasing HDL cholesterol. Also causes peripheral vasodilation, especially cutaneous vessels.

Drug Interactions ::

 Interactions

Adrenergic-blocking agent: May potentiate hypotensive effect. HMG-CoA reductase inhibitors: Increased risk of myopathy and rhabdomyolysis.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • If giving for hyperlipidemia, check baseline and monitor cholesterol level.
  • Check blood glucose, liver function tests, and uric acid level as ordered.
  • Monitor vital signs.
  • Assess for signs of jaundice, light-colored stools, dizziness, or faint feeling.
  • Notify physician of changes from baseline assessment.
OVERDOSAGE: SIGNS & SYMPTOMS
  Nausea, dizziness, pruritus, vomiting, tachycardia, GI distress, hypotension, flushing

Drug Storage/Management ::

 Administration/Storage

  • When giving orally, start with small doses, then increase gradually.
  • Administer with food.
  • Do not crush or break oral medication.

Drug Notes ::

 Patient/Family Education

  • Tell patient not to break up medication if taking orally.
  • Explain that flushing may appear after taking medication but should dissipate with continued therapy.
  • Tell patient to take medication with food.
  • Identify specific elements of well-balanced, low-fat diet.
  • Instruct patient to report the following symptoms to physician: jaundice, light-colored stools, excessive thirst, urinary frequency, dizziness, or faint feeling.
  • Caution patient to avoid sudden position changes, especially lying to sitting, to prevent dizziness.
  • Advise patient to avoid intake of alcoholic beverages or hot drinks and large doses of medication (> 500 mg) at one time to minimize flushing and warmth sensation.
  • Advise diabetic patients to notify physician if a change in blood glucose occurs.
  • Instruct patient to inform physician if taking vitamins or other nutritional supplements containing niacin or a related compound such as nicotinamide.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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