Details About Generic Salt ::  Rimantad

Main Medicine Class:: infective, Antiviral   

(rih-MAN-tuh-deen HIGH-droe-KLOR-ide)
Flumadine
Syrup: 50 mg/5 mL
Tablets: 100 mg
Class: infective, Antiviral

 

Drugs Class ::

 Action Inhibits viral replication cycle in various strains of influenza A virus.

Indications for Drugs ::

 Indications

Adults

Prophylaxis and treatment of infection caused by various strains of influenza A virus.

Children

Prophylaxis against influenza A virus.

Drug Dose ::

 Route/Dosage

Prophylaxis and Treatment

ADULTS: PO 100 mg bid.

ELDERLY Nursing Home Patients, Hepatic and Renal Impairment (Ccr < 10 mL/min): Reduce to 100 mg/day.

Prophylaxis

CHILDREN ³ 10 yr: PO 100 mg bid.

CHILDREN < 10 yr: PO 5 mg/kg/day (max, 150 mg/dose).

Contraindication ::

 Contraindications Hypersensitivity to drugs of adamantine class including rimantadine and amantadine.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Do not administer to nursing mothers. Children: Safety and efficacy for prophylaxis not established in children < 1 yr. Elderly: CNS symptoms may occur more frequently. Seizures: Increased incidence of seizures in patients with seizure history and who receive amantadine.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Insomnia; dizziness; headache; nervousness; asthenia; impaired concentration. EENT: Eye pain. GI: Nausea; vomiting; anorexia; dry mouth; abdominal pain.

Drug Mode of Action ::  

 Action Inhibits viral replication cycle in various strains of influenza A virus.

Drug Interactions ::

 Interactions

Acetaminophen, Aspirin

Decreased peak serum concentration of rimantadine.

Cimetidine

Increased serum concentration caused by decreased clearance.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess baseline renal and LFT results.
  • Notify health care provider if patient has seizure activity, severe or persistent diarrhea, dizziness, impaired concentration, asthenia, or dyspnea.
OVERDOSAGE: SIGNS & SYMPTOMS
  Agitation, cardiac arrhythmias, hallucinations, death

Drug Storage/Management ::

 Administration/Storage

  • Administer orally only.
  • Store at room temperature.

Drug Notes ::

 Patient/Family Education

  • Tell patient with history of seizures to discontinue drug and notify health care provider if seizure activity develops.
  • Instruct patient to report insomnia, dizziness, headache, nervousness, asthenia, impaired concentration, nausea, vomiting, anorexia, persistent diarrhea, dry mouth, abdominal pain, dyspnea, cough, palpitations, or syncope.
  • Caution patient to avoid driving or operating hazardous equipment if dizziness or confusion develops.
  • Advise patient to take drug several hours before going to bed if insomnia develops.

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Disclaimer ::

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