The Brand Name ACETEC Has Generic Salt :: ACITRETIN 

ACETEC  Is From Company Dr.Reddy’S Priced :: Rs. 584

ACETEC have ACITRETIN is comes under Sub class Anti Psoriatic Drugs of  Main Class Skin

Main Medicine Class:: Skin  Sub Medicine Class :: Anti Psoriatic Drugs 

Indications for Drugs ::

Lichen planus, Psoriasis, Congenital icthyosis, Darier’s disease

Drug Dose ::

Oral Darier’s disease Adult: Initially, 10 mg daily for 2-4 wk. Max: 50 mg/day. Congenital icthyosis Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods. Severe psoriasis Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods. Severe lichen planus Adult: Initially, 25-30 mg daily for 2-4 wk before dose adjustments are done. Usual range: 25-50 mg daily for further 6-8 wk. Max: 75 mg daily for short periods. Child: 500 mcg/kg/day. Max: 35 mg daily.

Contraindication ::

Pregnancy (before the start, during and at least 2-3 yr after cessation of therapy), lactation. Hepatic and renal impairment. Hyperlipidaemia.

Drug Precautions ::

Female patients to avoid alcohol during and 2 mth after treatment. Avoid blood donation during therapy or at least 1-3 yr after stopping therapy. Children. Radiographic treatment for prolonged therapy. Therapy should not last >6 mth. Monitor plasma lipid and glucose levels (especially diabetics) regularly. Monitor LFTs.

Drug Side Effects ::

Dryness of mucous membranes and skin; conjunctivitis, dry sore mouth; ophth disturbances; raised lipid level, pancreatitis; sticky skin, dermatitis. Severe headache; GI disturbances; dermatologic reactions, oedema, paronychia, granulomatous lesions, bullous eruptions; reversible hair thinning and alopoecia; CNS disturbances; sweating; taste disturbance, gingivitis; benign intracranial hypertension; photosensitivity; skeletal hyperostosis; extraosseous calcification; premature epiphyseal closure in child. Potentially Fatal: Phototoxicity, jaundice, hepatitis and hepatotoxity.

Pregnancy category ::

5

Drug Mode of Action ::  

Acitretin is an active metabolite of etretinate but its mechanism of action is unknown.

Drug Interactions ::

Concomitant use with keratolytics or high dose vitamin A. Reduces anticoagulant effect of coumarins e.g. warfarin. Concomitant use of microdised progestin oral contraceptives. Concomitant use of methotrexate can potentiate hepatotoxicty. Concomitant use with tetracycline.