Article Contents ::
Details About Generic Salt :: Ambrisentan
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
4H. MISCELLANEOUS in 4. CARDIOVASCULAR SYSTEM |
AMBRISENTAN |
ENDOTHELIN RECEPTOR ANTAGONIST | VASODILATOR |
PK: A: Rapid E: Liver |
Indications & Dose: PULMONARY HYPERTENSION PO Adult Initially 5mg OD, dose may be increased to 10mg OD |
Contra: Moderate- to-severe hepatic impairment, patients with hypotension
Precautions: Avoid abrupt withdrawal ADR: Serious: Hypotension, anaphylaxis, angioedema, anemia, muscle cramps, hepatic failure, hepatic cirrhosis, increases in liver aminotransferases, palpitations, flushing, Others: dizziness, GI disturbances, skin rashes, fatigue, pruritus, headache, nasopharyngitis DDI: Serious Ketoconazole modestly increases drug level |