Indications & Dose: ASTHMA Acute/Severe IV Child 1 month-18 yr: 5mg/kg over 20 min max 500mg followed by infNot previously treated with theophylline | BRONCHOSPASM Chronic PO Adult Modified-release preparation: 225-450mg BID | Acute/Severe IV Adult Slow Inj/Inf: Loading dose 5 mg/kg or 250-500mg over 20-30 min, MD 500µg/kg/h. Patients with cor pulmonale, HF, liver disease may require lower MD Child 6 month-10 yr: 1mg/kg/h, 10-16 yr: 800µg/kg/h | NEONATAL APNOEA IV Child Neonate: Initially 6mg/kg over 20min, then 2.5mg/kg BID, increase to 3.5mg/kg BID if needed

Precautions: PUD, hyperthyroidism, HTN, cardiac arrhythmias, CVD, HF, hepatic dysfunction, acute febrile illness, neonates, elderly, administer the drug slowly to prevent CNS & cardiovascular adverse effects, do not switch from one modified release aminophylline preparation to another without clinical assessment

ADR: Serious: sinus tachycardia, supraventricular & ventricular premature contractions, urinary retention, erythematous rash, erythroderma, exfoliative dermatitis, convulsions, Others: GI irritation, CNS stimulation, pruritus

DDI: Serious Imipenem causes seizures, Phenytoin/Carbamazepine/Rifampicin/Ritonavir decreases drug level, Enoximone efficacy decreases in pre-term neonates, Isoprenaline/Aminoglutethimide/Phenobarbital/Sulfinpyrazone/Tobacco increases drug clearance, Cimetidine/Aciclovir/Ciprofloxacin/Erythromycin/Fluvoxamine/Methoxsalen/Minocycline/Pentoxifylline/Tacrine/Tetracycline/Vidarabine increases drug level, Phenylpropanolamine/Diltiazem/Propranolol reduces drug clearance

Diet: With/Without food

Monitor: ECG, CNS effects, respiratory rate, arterial/capillary blood gases,theophylline concentration