Indications & Dose: ACUTE OTITIS MEDIA PO Child 90mg/kg amoxicillin 6.4mg/kg clavulanic acid divided q12h 10days | BITE WOUNDS PO Adult 875mg q12h or 500mg q8h Child >16 yr: Same as adult doseAnimal/human | CHANCROID PO Adult 500mg amoxicillin 125 or 250mg clavulanic acid q8h 7 days | CHRONIC OBSTRUCTIVE PULMONARY DISEASE PO Adult 875mg q12h or 500mg q8h Child >16 yr: 875mg q12h or 500mg q8h | COMMUNITY-ACQUIRED PNEUMONIA PO Adult ER tablet: 1g q12h 7-10 days Child >40 kg: 875mg q12h or 500mg q8h >3 months or <40 kg: 20-45mg/kg/day in 2 divided doses or 20-40mg/kg/day in 3 divided doses | DIABETIC FOOT PO Adult ER tablet: Two 1g tablets q12h 7-14 days Child >16 yr: Same as adult dose | DIVERTICULITIS PO Adult ER tablet: Two 1g tablets q12h 7-10 days Child >16 yrs: Same as adult dose | ERYSIPELAS PO Adult 875mg q12h or 500mg q8h Child >16 yr: Same as adult dose | FEBRILE NEUTROPENIA PO Adult 875mg q12h Child >16 yr: 875mg q12h | GONORRHEA PO Adult single dose amoxicillin 3g clavulanic acid 125-500mg with/without oral probenecid (1g) | INFECT Severe PO Adult 500mg coated tab (500mg amoxicillin & 125mg clavulanic acid) q8h or 875mg scored tablet (875mg amoxicillin & 125mg clavulanic acid) q12h | LOWER RESPIRATORY TRACT INFECT Severe PO Child >3 months & <40 kg: 45mg/kg/day divided q12h or 40 mg/kg/day divided q8h | Mild-to-moderate PO Child >3 months & <40 kg: 25mg/kg/day divided q12h or 20 mg/kg/day divided q8h | PERIRECTAL ABSCESS PO Adult ER tablet: Two 1g tablets q12h 7-10 days Child >16 yr: Same as adult dose | PHARYNGITIS PO Adult 500mg BID 10 days Child 40mg/kg/day, max 750mg/day in 3 divided doses 10 days | PYELONEPHRITIS Acute/Uncomplicated PO Adult 875mg q12h or 500mg q8h Child >16 yr: Same as adult dose | RESPIRATORY TRACT INFECT PO Adult 500mg coated tab (500mg amoxicillin & 125mg clavulanic acid) q8h or 875mg scored tablet (875mg amoxicillin & 125mg clavulanic acid) q12h | SEVERE INFECT Severe PO Child >3 months & <40 kg: 45mg/kg/day divided q12h or 40 mg/kg/day divided q8h | SINUSITIS PO Child >3 months & <40 kg: 45mg/kg/day divided q12h or 40 mg/kg/day divided q8h | SKIN ABSCESS PO Adult 875 mg q12h Child >16 yr: Same as adult dose | TONSILLITIS PO Adult 500mg BID 10 days Child 40 mg/kg/day, max 750mg/day 3 divided doses 10 days

Precautions: Severe renal insufficiency, infectious mononucleosis, asthma

ADR: Serious: bone marrow depression, hepatitis, pseudomembranous colitis, interstitial nephritis, seizures, anaphylaxis, hypersensitivity, SJS, TEN, urticaria, erythema multiforme, superinfections, blood disorders, crystalluria, Others: agitation, anxiety, confusion, dizziness, headache, insomnia, lethargy, hallucinations, nausea, vomiting, diarrhea, gastritis, black hairy tongue, enterocolitis

DDI: Serious Typhoid vaccine efficacy reduces, Allopurinol enhances potential for allergic/hypersensitivity reactions of drug, Mycophenolate Impaired enterohepatic recirculation, Coumarins increased PT & bleeding, Probenecid increases drug concentration, Methotrexate leads to acute toxicity, Fusidic acid/BCG therapeutic effects are reduces, Tetracyclines therapeutic efficacy is reduced

Diet: With/without food

Monitor: Renal functions, LFTs, CBC, signs of anaphylaxis