Article Contents ::
Details About Generic Salt :: Anastrozole
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| ANASTROZOLE |
| NONSTEROIDAL AROMATASE INHIBITOR | ANTI-NEOPLASTIC |
| PK: A: Rapid & complete M: Hepatic E: Urine & feces |
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Indications & Dose: ADVANCED BREAST CANCER Second-line therapy PO Adult Postmenopausal: 1mg/day given after tamoxifen therapy until tumor progression is evident | EARLY STAGE BREAST CANCER Adjuvant therapy PO Adult Postmenopausal: 1mg/day | LOCALLY ADVANCED/METASTATIC BREAST CANCER First-line therapy PO Adult Postmenopausal: 1mg/day until tumor progression is evident |
| Contra: Children, premenopausal women, hypersensitivity
Precautions: Hyperlipidemias, risk of osteoporosis ADR: Serious: SJS, bone fractures, thromboembolism, vasodilation, HTN, pelvic pain, myocardial ischemia, cataract, osteoporosis, vaginal bleeding/dryness, lymphedema, anaphylaxis, Others: thrombophlebitis, hepatitis/increased ALP, peripheral edema, hypercholesterolemia, dyspnea, nausea, rash, weakness, constipation, abdominal pain, weight loss, vomiting, anorexia, diarrhea DDI: Serious Tamoxifen Reduces drug level Diet: With/without food Monitor: Bone mineral density,total cholesterol, LDL |
