Details About Generic Salt ::  Anastrozole 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
ANASTROZOLE
NONSTEROIDAL AROMATASE INHIBITOR | ANTI-NEOPLASTIC
PK: A: Rapid & complete M: Hepatic E: Urine & feces

Indications & Dose: ADVANCED BREAST CANCER Second-line therapy PO Adult Postmenopausal: 1mg/day given after tamoxifen therapy until tumor progression is evident | EARLY STAGE BREAST CANCER Adjuvant therapy PO Adult Postmenopausal: 1mg/day | LOCALLY ADVANCED/METASTATIC BREAST CANCER First-line therapy PO Adult Postmenopausal: 1mg/day until tumor progression is evident

Contra: Children, premenopausal women, hypersensitivity

Precautions: Hyperlipidemias, risk of osteoporosis

ADR: Serious: SJS, bone fractures, thromboembolism, vasodilation, HTN, pelvic pain, myocardial ischemia, cataract, osteoporosis, vaginal bleeding/dryness, lymphedema, anaphylaxis, Others: thrombophlebitis, hepatitis/increased ALP, peripheral edema, hypercholesterolemia, dyspnea, nausea, rash, weakness, constipation, abdominal pain, weight loss, vomiting, anorexia, diarrhea

DDI: Serious Tamoxifen Reduces drug level

Diet: With/without food

Monitor: Bone mineral density,total cholesterol, LDL

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