Article Contents ::
Details About Generic Salt :: Asparaginase
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| ASPARAGINASE |
| ENZYME | ANTI-NEOPLASTIC |
| PK: D: 4-5L/kg (Vd) E: Little |
|
Indications & Dose: ACUTE LYMPHOBLASTIC LEUKEMIA Mono therapy IV Adult Induction of remission: 1000U/kg/day for 10 days after treatment with vincristine, prednisone/prednisoloneAdministered with 0.9% NaCl/ 5% dextrose for 30 min | IM Adult Induction of remission: 6000U/m2 qthird day for 9 doses during treatment with vincristine, prednisone/prednisolone2ml should be given at one site |
| Contra: Hypersensitivity, pancreatitis, thrombosis, serious hemorrhage
Precautions: Bone marrow depression, CNS depression, renal/hepatic disease ADR: Serious: anaphylaxis, hypersensitivity, bronchospasm, seizures, hyperuricemia, ketoacidosis, hypoalbuminemia, hyperammonemia, renal failure, leucopenia, Parkinson like syndrome, Others: nausea, vomiting, CNS disturbances, drowsiness, stomatitis, weight loss, fever, chill, hyperglycemia DDI: Serious Vincristine causes neurotoxicity, Imatinib leads to hepatotoxicity Monitor: CBC, urinalysis, LFTs, coagulation parameters, renal functions, blood glucose,uric acid,allergic reactions & mental status |
