The Brand Name BLEONCO Has Generic Salt :: Bleomycin 

BLEONCO  Is From Company VHB Priced :: Rs. 630

BLEONCO have Bleomycin is comes under Sub class Anti Neoplastic Agents of  Main Class Anti Neoplastic Agents

Main Medicine Class:: Anti Neoplastic Agents  Sub Medicine Class :: Anti Neoplastic Agents 

Indications for Drugs ::

Lymphoma, Squamous cell or Testicular tumours, Malignant effusions

Drug Dose ::

Parenteral Squamous cell or testicular tumours Adult: 15,000 IU 3 times a wk or 30,000 IU twice a wk IM/IV, repeated at usual intervals of 3-4 wk up to a total cumulative dose of 500,000 IU. Elderly: Dose reduction is necessary. Intramuscular Lymphoma Adult: 15,000 IU once or twice a wk, up to a total cumulative dose of 225,000 IU. Elderly: Dose reduction is necessary. Injection Malignant effusions Adult: 60,000 IU in 100 ml of 0.9% sodium chloride instilled into the affected serous cavity, may be repeated up to a total cumulative dose of 500,000 IU. Elderly: Dose reduction is necessary.

Contraindication ::

Hypersensitivity. Severe pulmonary disease; pregnancy and lactation.

Drug Precautions ::

Pulmonary infection, preexisting pulmonary function impairment, renal impairment. Patients who received radiotherapy, particularly to the thorax. Regular chest x-rays should be done. Elderly. Discontinue treatment if chest x-rays show infiltrates or breathlessness occurs.

Drug Side Effects ::

Fever, thrombophloebitis (inj). Acute anaphylactoid reactions, hyperpyrexia. Rash, erythema, pruritus, vesiculation, hyperkeratosis, nail changes, alopecia, hyperpigmentation, striae, stomatitis. Potentially Fatal: Pulmonary toxicity, interstitial pneumonitis, fibrosis, cardiorespiratory collapse in patients with lymphoma.

Pregnancy category ::

4

Drug Mode of Action ::  

Bleomycin causes breakage of single- and double- stranded DNA by binding to DNA and inhibiting DNA synthesis. To a lesser extent, it also inhibits RNA and protein synthesis. It causes very little bone marrow suppression.

Drug Interactions ::

Increased incidence and severity of lung toxicity w/ previous or concurrent radiotherapy to the chest. Combination w/ vinca alkaloids may result to a syndrome corresponding to morbus Raynaud, ischaemia which can lead to necrosis of peripheral parts of the body (fingers, toes, nose tip). May reduce the absorption of phenytoin. Increased risk of agranulocytosis w/ clozapine. Potentially Fatal: Increased pulmonary toxicity w/ oxygen, cisplatin or brentuximab.