The Brand Name CAPTABIN Has Generic Salt :: CAPECITABINE 

CAPTABIN  Is From Company Shantha Bio. Priced :: Rs. 1450

CAPTABIN have CAPECITABINE is comes under Sub class Anti Neoplastic Agents of  Main Class Anti Neoplastic Agents

Main Medicine Class:: Anti Neoplastic Agents  Sub Medicine Class :: Anti Neoplastic Agents 

Indications for Drugs ::

Breast cancer, Colorectal cancer, Gastric cancer, Oesophageal cancer

Drug Dose ::

Adult: PO Colorectal cancer; Breast cancer 1.25 g/m2 twice daily for 14 days followed by a 7-day rest period. Treatment duration for colorectal cancer: 6 mth. Gastric cancer W/ platinum-based compd: 1 g/m2 twice daily for 14 days, followed by a 7-day rest period. Renal impairment: CrCl (ml/min) 51-80 No adjustment needed. 30-50 Reduce dose to 950 mg/m2 bid when starting dose is 1.25 g/m2 bid. No dose adjustment is needed when starting dose is 1 g/m2. <30 Avoid use. Contraindication ::

History of severe and unexpected reactions to fluoropyrimidine therapy; severe renal impairment; pregnancy, lactation. Hypersensitivity.

Drug Precautions ::

Hepatic dysfunction, bone marrow suppression, poor nutritional status, warfarin therapy. Child, elderly, prior extensive pelvic radiation or alkylating therapy. Moderate renal impairment; CBC with differential; monitor hepatic and renal function. Discontinue use if intractable diarrhoea, stomatitis, bone marrow suppression or MI develops.

Drug Side Effects ::

Diarrhoea, nausea and vomiting, stomatitis, palmar-plantar syndrome, dermatitis. Fatigue, mucosal inflammation, pyrexia, asthenia and lethargy; headache, dizziness and insomnia; lower limb oedema, anorexia, dehydration. Potentially Fatal: Cardiotoxicity, bone-marrow depression and hyperbilirubinaemia.

Pregnancy category ::

4

Drug Mode of Action ::  

Capecitabine is a prodrug that is converted to fluorouracil following oral administration, which in turn inhibits thymidylate synthetase, blocking the methylation of deoxyuridylic acid to thymidylic acid, interfering with DNA, and to a lesser degree, RNA synthesis.

Drug Interactions ::

Antacids containing aluminum and magnesium, leucovorin, anticoagulants, phenytoin, allopurinol.