Article Contents ::
Details About Generic Salt :: Carboplatin
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| CARBOPLATIN |
| ALKYLATING AGENT | ANTI-NEOPLASTIC |
| PK: D: 16 L (Vd) M: Hepatic E: Urine |
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Indications & Dose: ADVANCED OVARIAN CANCER Combination therapy IV Adult 300mg/m2 as inf over 15-60min q4wk with cyclophosphamide | Mono therapy IV Adult 360mg/m2 as inf over 15-60min q4wk |
| Contra: History of severe allergic reaction, severe bone marrow depression/significant bleeding, renal/hearing impairment, contact with skin & eyes, acute infect
Precautions: Renal impairment, elder, debilitated patients ADR: Serious: Electrolyte distubance, myelosuppression, blood disorders, AST/alkaline phosphatase increased, Clcr decreased, BUN increased, Hypersensitivity/allergic reaction, neurotoxicity, hemorrhagic complications, peripheral neuropathy, visual disturbance, ototoxicity, infect, Others: alopecia, constipation, diarrhea, weakness, vomiting, abdominal pain, nausea, Pain DDI: Serious Etoposide clearance modestly reduces by drug, Warfarin effects increases, Paclitaxel leads to neurotoxicity Monitor: CBC with differential & platelet count, serum electrolytes, SeCr & BUN, Clcr, LFTs |
