Indications & Dose: CELLULITIS IV Adult 2g q4h Child >12 yr: Same as adult doseOrbital | EPIGLOTTITIS Combination therapy IV Adult 2g q4-8h Child 1 month-12 yr: 150-200mg/kg/day 4divided doses 7-10 days with clindamycin, >12 yr: Same as adult dose | GONORRHOEA IV Adult 1g TID Child >12 yr: Same as adult doseDisseminated | IM Adult 1g single dose Child >12 yr: Same as adult dose | LIFE-THREATENING INFECT IV Adult 2g q4h Child >12 yr: Same as adult dose | LIVER ABSCESS IV Adult 1-2g q6h Child >12 yr: Same as adult dose | LYME DISEASE IV Adult 2g q4h (cardiac manifestations), 2g q8h 14-28 days (CNS manifestations) Child >12 yr: Same as adult dose | MENINGITIS IV Adult 2g q4-6h Child 1 month-12 yr: 200mg/kg/day in divided doses q6h, >12 yr: Same as adult dose | MODERATE TO SEVERE INFECT IV/IM Adult 1-2g q8h Child >12 yr: Same as adult dose | PNEUMONIA IV Child 1 month-12 yr: 200mg/kg/day TID | SEPSIS IV Child 1 month-12 yr: 150mg/kg/day TID | SEPTIC ARTHRITIS IV Adult 1g q8h Child >12 yr: Same as adult dose | SURGICAL INFECT Prophylactic therapy IV/IM Adult 1g 30-90min before surgery Child >12 yr: Same as adult dose | TYPHOID FEVER IV/IM Child 1 month-12 yr: 150-200mg/kg/day in 3-4 divided doses, max 12g/day

Precautions: Renal impairment, history of penicillin allergy, phenylketonuria, children, elderly

ADR: Serious: arrhythmias, granulocytopenia, BUN increased, thrombocytopenia, TEN, anaphylaxis, interstitial nephritis, neutropenia, diarrhea, Others: nausea, vomiting, headache, fever, erythema multiforme, pruritus, pain at Inj site

DDI: Serious Phenobarbital causes exanthematous skin reactions, Probenecid decreases drug elimination, Gentamicin leads to nephrotoxicity

Monitor: CBC,signs & symptoms of anaphylaxis