Indications & Dose: GONORRHEA Uncomplicated IM Adult 1g as single dose | INFECT Severe IV Adult 2-4g TID, doses up to 2g q4h may be given in life-threatening infect Child > 6 months: 50mg/kg TID/QID | URINARY TRACT INFECT Uncomplicated IV Adult 500mg BID

Precautions: Penicillin-sensitive patients, history of allergy, renal impairment, false positive Coombs’ test, false-positive reactions for glucose using copper-reduction reactions, false Jaffé method of measuring creatinine levels

ADR: Serious: hypersensitivity reactions, blood disorders, anaphylaxis, bleeding complications, hypoprothrombinemia, platelet dysfunction, nephrotoxicity, acute interstitial nephritis, hepatitis, transient increases in liver enzyme values, cholestatic jaundice, convulsions, CNS toxicity, overgrowth of non-susceptible organisms, pseudomembranous colitis, thrombophlebitis, Others: skin rashes, urticaria, eosinophilia, fever, nausea, vomiting, diarrhea, pain at inj site, local reactions

DDI: Serious Probenecid reduces drug renal clearance