The Brand Name COLCHICINDON Has Generic Salt :: Colchicine 

COLCHICINDON  Is From Company Zydus A. Priced :: Rs. 12.08

COLCHICINDON have Colchicine is comes under Sub class Anti Gout Drugs of  Main Class Musculoskeletal Disorders , Pain

Main Medicine Class:: Musculoskeletal Disorders , Pain  Sub Medicine Class :: Anti Gout Drugs 

Indications for Drugs ::

Acute gout, Familial Mediterranean Fever, Behcet’s disease, Gouty arthritis

Drug Dose ::

Adult: PO Acute gout Initial: 1 mg, reduce to 0.5 mg 2-3 hrly until pain relief is achieved or GI toxicity occurs. Max: 6 mg/course. May repeat course after at least 3 drug-free days. Prophylaxis of recurrent gouty arthritis 0.5-0.6 mg once daily.

Contraindication ::

Hypersensitivity; blood dyscrasias, severe renal impairment, pregnancy, debilitated patients; SC/IM admin.

Drug Precautions ::

Elderly; GI disease. Cardiac, renal and hepatic impairment; prolonged therapy not recommended; lactation.

Drug Side Effects ::

Nausea, vomiting and abdominal pain; diarrhoea, GI haemorrhage, rashes, renal and hepatic damage in excessive doses. Rarely peripheral neuritis, myopathy, alopecia and with chronic therapy blood disorders like agranulocytosis, aplastic anaemia.

Pregnancy category ::

4

Drug Mode of Action ::  

Colchicine, a phenanthrene derivative, exerts its effect by reducing the inflammatory response to the deposited urate crystals and also by diminishing phagocytosis in joints. It inhibits lactic acid production by leucocytes, thereby interrupting urate deposition and inflammatory response that sustains the acute gout attack.

Drug Interactions ::

Reversible malabsorption of vitamin B12 may occur because of ileal mucosal function alteration. Response to CNS depressants and sympathomimetics may increase when used concurrently with colchicine. Increased risk of myopathy when used concurrently with simvastatin. Potentially Fatal: With ciclosporin, increased risk of nephrotoxicity and myotoxicity. Risk of colchicine toxicity when used with macrolides.