Indications & Dose: BREAST CANCER PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | HODGKIN’S LYMPHOMA PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | LYMPHOCYTIC LEUKEMIA Acute/Chronic PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | Acute/Chronic IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | MULTIPLE MYELOMA PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | MYCOSIS FUNGOIDES PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | MYELOCYTIC LEUKEMIA Acute/Chronic PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | Acute/Chronic IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | NEPHROTIC SYNDROME PO Child 2.5-3mg/kg/day 60-90 days | NEUROBLASTOMA PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | NON-HODGKIN’S LYMPHOMA PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | OVARIAN ADENOCARCINOMA PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals | RETINOBLASTOMA PO Adult Initial dose & MD: 1-5mg/kg/day Child Same as adult dose | IV Adult 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals Child 400mg-1.8g/m2 or 30-50mg/kg per treatment course (1-5 days), may be repeat at 2-4 wk intervals

Precautions: Hepatic/renal impairment, DM, elderly/debilitated patients, who have undergone adrenalectomy

ADR: Serious: Sterility, acute hemorrhagic cystitis, urinary fibrosis, blood disorders, facial flushing, anaphylactic reactions, acute respiratory distress syndrome, acute respiratory distress syndrome, hepatotoxicity, SJS, TEN, Others: Alopecia, headache, skin rash, nausea, vomiting, anorexia, diarrhea, mucositis

DDI: Serious Ofloxacin/Ciprofloxacin/Verapamil absorption reduces by drug, Amiodarone causes pulmonary toxicity, HIV protease inhibitors clearance reduces modestly by drug, Suxamethonium effects increases & prolongs its effect by drug, Warfarin increases anti-coagulant effect by drug, Busulfan increases drug level & decreases its active metabolite, Etanercept increases the incidence of malignancies in patients with Wegener’s granulomatosis, Itraconazole/Fluconazole inhibits drug metabolism, Azathioprine leads to liver damage, Chloramphenicol reduces the production of active metabolites of drug

Diet: With food

Monitor: CBC with DC & platelet count, BUN, UA, serum electrolytes, SeCr