Article Contents ::
Details About Generic Salt :: Dacarbazine
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
| 18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS |
| DACARBAZINE |
| ALKYLATING DRUG, TRIAZENE | ANTI-NEOPLASTIC |
| PK: D: 0.6 L/kg (Vd) M: Hepatic E: Urine (~40% as unchanged drug) |
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Indications & Dose: HODGKIN’S DISEASE Combination therapy IV Adult 375mg/m2 on days 1 & 15 with other anti-cancer drugs, regimen may be repeated q4wk Child Same as adult dose | METASTATIC MELANOMA IV Adult 250mg/m2/day for 5 days, repeated q3wk |
| Contra: Hypersensitivity
Precautions: Hepatic/renal impairment, impaired bone marrow function, children ADR: Serious: myelosuppression, leukopenia, thrombocytopenia, anaphylactic reactions, hepatic necrosis, renal functions test abnormalities, Others: paresthesia, diarrhea, erythema, facial flushing, pain on inf, alopecia, nausea, vomiting, anorexia DDI: Serious Levodopa effects reduces by drug Monitor: CBC with differential, LFTs |
