Article Contents ::
- 1 The Brand Name DARAMIN Has Generic Salt :: Pyrimethamine
- 2 DARAMIN Is From Company Indica Priced :: Rs. 5.12
- 3 DARAMIN have Pyrimethamine is comes under Sub class #N/A of Main Class #N/A
- 4 Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
- 5 Disclaimer ::
- 6 The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.
The Brand Name DARAMIN Has Generic Salt :: Pyrimethamine
DARAMIN Is From Company Indica Priced :: Rs. 5.12
DARAMIN have Pyrimethamine is comes under Sub class #N/A of Main Class #N/A
Main Medicine Class:: #N/A Sub Medicine Class :: #N/A
| Salt Name : OR Generic Name | Form | Price : MRP /Probable | Packing | ||
| Pyrimethamine | TAB | Rs. 5.12 | 10 |
| Brand Name | Company / Manufacturers | Strength | Unit | Price / 10 |
| DARAMIN | Indica | 25MG | 10 | Rs. 5.12 |
| Company Brand Name | Salt Combination | Main Medical Class | Sub Medical Class |
| From Indica :: DARAMIN | Pyrimethamine | #N/A | #N/A |
Indications for Drugs ::
Acute malaria,Malaria prophylaxis,Toxoplasmosis
Drug Dose ::
Oral Acute malaria Adult: As a single dose, in combination with a sulfonamide: 75 mg pyrimethamine with 1.5 g sulfadoxine. Child: 7-13 yr: 50 mg pyrimethamine with 1 g sulfadoxine; 1-6 yr: 25 mg pyrimethamine with 500 mg sulfadoxine; 5-11 mth: 12.5 mg pyrimethamine and 250 mg sulfadoxine. To be taken as a single dose, in combination with a sulfonamide. Prophylaxis of malaria Adult: Pyrimethamine 25 mg as single dose once wkly. 1st dose should be taken 1-2 days before arrival in the endemic area, continue admin during stay and for 4-6 wk after leaving the area. Child: <4 yr: 6.25 mg once wkly; 4-10 yr: 12.5 mg once wkly; >10 yr: 25 mg once wkly. 1st dose should be taken 1-2 days before arrival in the endemic area, continue admin during stay and for 4-6 wk after leaving the area. Toxoplasmosis Adult: 50-75 mg pyrimethamine daily with 1-4 g sulfadiazine daily. Continue at this dosage for 1-3 wk, depending on the patient’s response and tolerance, then half the dosage and continue for another 4-5 wk. Child: 1 mg/kg daily 2-4 days then 0.5 mg/kg daily for another 4 wk with usual paediatric dose of sulfadiazine.
Contraindication ::
Hypersensitivity, resistant malaria, megaloblastic anaemia secondary to folate deficiency. Pregnancy and lactation.
Drug Precautions ::
Renal or hepatic impairment; folate deficiency; monitor blood and platelet counts every 2 wk with prolonged treatment and large doses. Discontinue use if skin reactions, sore throats or shortness of breath occurs.
Drug Side Effects ::
Rashes, macrocytic anaemia (high dose), leucopenia, thrombocytopenia, megaloblastic anaemia, pancytopenia, abdominal pain, vomiting, atrophic glossitis. Potentially Fatal: Cutaneous reactions e.g. erythema multiforme and Stevens-Johnson syndrome and toxic epidermal necrolysis with sulfadoxine at large doses.
Pregnancy category ::
3
Drug Mode of Action ::
Pyrimethamine is a folic acid antagonist structurally similar to trimethoprim. It inhibits parasitic dihydrofolate reductase, thus inhibiting vital tetrahydrofolic acid synthesis. It is active against pre-erythrocytic forms and is also a slow-acting schizontocide.
Drug Interactions ::
Lorazepam may induce hepatotoxicity. Increased risk of bone marrow suppression when used with agents that have myelosuppressive properties e.g. proguanil, sulfonamides, zidovudine and cytostatic agents. Increased risk of serious pancytopenia and megaloblastic anaemia when used with co-trimoxazole or other sulfonamides.
