Article Contents ::
Details About Generic Salt :: Disulfiram
Main Medicine Class:: Nervous System Sub Medicine Class :: Drugs for Substance Abuse
| 1K. DRUGS FOR SUBSTANCE ABUSE in 1. NERVOUS SYSTEM |
| DISULFIRAM |
| ALDEHYDE DEHYDROGENASE INHIBITOR | ANTIDOTE |
| PK: A: Rapid M: Hepatic E: Urine |
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Indications & Dose: CHRONIC ALCOHOLISM PO Adult Initially 500mg/day 1-2 wk, followed by a MD of 250mg/day, range 125-500mg/day, maintenance therapy may be required for months or yrs |
| Contra: CVD, psychosis, hypersensitivity to drug/other thiuram compounds, severe personality disorders, suicide risk
Precautions: DM, epilepsy, renal/hepatic impairment, respiratory disorders, cerebral damage, hypothyroidism, ensure that alcohol not consumed for at least 24 h before initiating treatment ADR: Serious: drowsiness & fatigue, halitosis, reduced libido, peripheral neuritis, hepatic cell damage, schizophrenia, allergic dermatitis, tachycardia, palpitations, marked hypotension, respiratory depression, convulsions, myocardial infarction, cardiovascular collapse, Others: paranoia, sweating, thirst, confusion, weakness, nausea & vomiting, depression DDI: Serious Metronidazole causes acute psychoses & confusion, Phenytoin levels are markedly & rapidly increased and leads to toxicity, Diazepam/Chlordiazepoxide plasma levels are increased, Isoniazid results a changes in mental status, behaviour & drowsiness, Alcohol results in flushing & fullness of face & neck, tachycardia, breathlessness, giddiness, hypotension, nausea & vomiting Monitor: Liver function tests, complete CBC & serum chemistries, potassium concentration |