The Brand Name DOBONIS Has Generic Salt :: Dobutamine 

DOBONIS  Is From Company NEISS Priced :: Rs. 180

DOBONIS have Dobutamine is comes under Sub class #N/A of  Main Class #N/A

Main Medicine Class:: #N/A  Sub Medicine Class :: #N/A 

Indications for Drugs ::

Heart failure, Cardiac stress test

Drug Dose ::

Adult: IV Acute heart failure 2.5-10 mcg/kg, up to 0.5-40 mcg/kg according to response. Cardiac stress test As 1 mg/mL soln: 5 mcg/kg/min for 8 mins, increase dose at 5 mcg/kg/min until 20 mcg/kg/min, w/ each dose being infused for 8 mins before the next increase. Because of its short half-life, Dobutamine Hydrochloride must be administered as a continuous intravenous infusion. Following the initiation of a constant rate infusion, or upon changing the rate, a steady-state dobutamine plasma concentration is achieved within approximately 10 minutes. Thus, loading doses or bolus injections are not necessary and are not recommended. Recommended Dosage The rate of infusion needed to increase cardiac output has ranged from 2.5 to 10 mcg/kg/min in the majority of patients. Frequently, doses up to 20 mcg/kg/min are required for adequate haemodynamic improvement. The rate of administration and the duration of therapy should be adjusted according to the patient’s response, The indicators are: haemodynamic parameters such as heart rate and rhythm, arterial pressure, and, whenever possible, cardiac output and measurements of ventricular filling pressures and signs of pulmonary congestion. Concentrations up to 5,000 mg/L have been administered to humans. The final volume administered should be determined by the fluid requirements of the patient. Rather than abruptly discontinuing therapy with Dobutamine Hydrochloride, it is often advisable to decrease the dosage gradually. Rates of Infusion Based on Concentration of Dobutamine Hydrochloride The rates of fluid infusion that are required to deliver specific dosages are a function of the concentration of Dobutamine Hydrochloride in the infusate.

Contraindication ::

Hypersensitivity; idiopathic hypertrophic subaortic stenosis (IHSS).

Drug Precautions ::

Correct hypovolaemia prior to treatment. Increased risk of rapid ventricular response in patients with atrial fibrillation. Insufficient data to determine the safety and efficacy of dobutamine use after acute MI. Elderly. Neonates. Pregnancy.

Drug Side Effects ::

Increased heart rate and BP, ectopic beats, palpitation. Nausea, headache, chest pain, palpitation, dyspnoea, paraesthesia, leg cramps. Tissue necrosis at site of extravasation. Potentially Fatal: Cardiac arrhythmias, allergy (rare), MI and hypotension.

Pregnancy category ::

2

Drug Mode of Action ::  

Dobutamine increases contractility and heart rate by stimulating ?-adrenergic receptors in the cardiac tissues.

Drug Interactions ::

Increased cardiac output when used with nitroprusside. Increased vasopressor effect of dobutamine when used with bretylium, guanethidine, oxytocic drugs or TCAs.