Indications & Dose: CARDIAC STRESS TESTING IV Adult 5µg/kg/min as inf for 8min, dose is increased by increments of 5µg/kg/min, max 20µg/kg/min for 8min | HEART FAILURE Short-term therapy IV Adult 2.5-20µg/kg/min as inf, max 40µg/kg/min, titrated to desired response Child Neonate: Initially 5µg/kg/min, adjusted according to response to 2-15µg/kg/min max 20µg/kg/ min, 1 month–18 yr: Initially 5µg/kg/min, adjusted according to response to 2-20µg/kg/min

Precautions: Atrial fibrillation, hypovolemia, post MI, cardiogenic shock, severe hypotension

ADR: Serious: Increases in HR & BP, ectopic beats, angina/chest pain, palpitation, ventricular tachycardia, cardiac rupture, thrombocytopenia, Others: Fever, headache, paresthesia, nausea, phlebitis, cutaneous necrosis, leg cramps, local inflammatory changes & pain from infiltration, dyspnea

DDI: Serious Atomoxetine causes additive effects on BP, Theophylline causes marked tachycardia, Dipyridamole causes potentially hazardous hypotension, COMT inhibitors decreases drug metabolism, Clonidine increases BP, β-blockers increases hypertensive effect of drug, Cimetidine leads to exaggerated hypertensive response, Vancomycin level reduces, Calcium compounds reduces cardiotonic effects of drug

Monitor: BP, ECG, HR, CVP, RAP, MAP, urine output