The Brand Name DORINOSA Has Generic Salt :: DORIPENEM 

DORINOSA  Is From Company Natco Ph. Priced :: Rs. 2950

DORINOSA have DORIPENEM is comes under Sub class Other Beta Lactams of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Other Beta Lactams 

Indications for Drugs ::

Intra-abdominal infections, Bacterial infections, Septicemia, Nosocomial pneumonia, Urinary tract infections, Pyelonephritis

Drug Dose ::

Adult: IV Complicated intra-abdominal infections; Complicated urinary tract infection; Pyelonephritis; Nosocomial pneumonia. 500 mg 8 hrly. Treatment duration: May range from 5-14 days. Renal impairment: CrCl (ml/min) 30-50 250 mg every 8 hr by IV infusion over 1 hr 11-29 250 mg every 12 hr by IV infusion over 1 hr

Contraindication ::

Hypersensitivity; anaphylactic reactions to beta-lactams.

Drug Precautions ::

May decrease serum concentration of valproic acid to below therapeutic range thus increasing risk of breakthrough seizure; consider alternative antimicrobial agents or additional anti-seizure medications if concurrent usage is necessary. Prolonged use may result in Clostridium difficile-associated diarrhoea (CDAD). May cause development of drug-resistant bacteria when used in the absence of proven or strongly suspected bacterial infection. Renal impairment. Safety and efficacy have not been established in patients <18 yr old. Drug Side Effects ::

Headache, nausea, diarrhoea, rash, phlebitis, elevated hepatic enzymes, oral candidiasis, anaemia, vulvomycotic infection, renal impairment, neutropenia, leucopenia, thrombocytopenia. Potentially Fatal: Anaphylaxis, toxic epidermal necrolysis, Stevens-Johnson Syndrome, interstitial pneumonia, seizure.

Pregnancy category ::

2

Drug Mode of Action ::  

Doripenem is a broad-spectrum carbapenem with potent in vitro antibacterial activity against aerobic and anaerobic gram-positive and gram-negative bacteria including Pseudomonas aeruginosa. It inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins; which in turn inhibits the final transpeptidase step of peptidoglycan synthesis in bacterial cell walls.

Drug Interactions ::

Increased plasma concentration w/ probenecid. May decrease plasma levels of valproic acid thus, increasing the risk of seizures.