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Details About Generic Salt :: Doripenem
Main Medicine Class:: Anti Infectives Sub Medicine Class :: Other Beta Lactams
| 13D. OTHER BETA LACTAMS in 13. ANTI-INFECTIVES |
| DORIPENEM |
| CARBAPENEM | ANTI-INFECTIVE |
| PK: D: 16.8L(Vd) M: Non-CYP mediated E: Urine (70%) & feces (1%) |
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Indications & Dose: INTRA-ABDOMINAL INFECT Complicated/Severe IV Adult Inf: 500mg TID 5-14 days over 1h | PYELONEPHRITIS IV Adult Inf: 500mg TID 10-14 days over 1h | URINARY TRACT INFECT Complicated IV Adult Inf: 500mg TID 10-14 days over 1h |
| Contra: Hypersensitivity, anaphylactic reactions to ß-lactam antibiotics
Precautions: Avoid prolong therapy, renal impairment ADR: Serious: phlebitis, renal impairment, SJS, TEN, anaphylaxis, Others: headache, nausea, diarrhea, oral candidiasis, anemia, pruritus DDI: Serious Probenecid increases drug plasma level Diet: Monitor: Signs & symptoms of anaphylaxis, RFT, CBC |