The Brand Name DTIC-VHB Has Generic Salt :: Dacarbazine 

DTIC-VHB  Is From Company Vhb Priced :: Rs. 519

DTIC-VHB have Dacarbazine is comes under Sub class Anti Neoplastic Agents of  Main Class Anti Neoplastic Agents

Main Medicine Class:: Anti Neoplastic Agents  Sub Medicine Class :: Anti Neoplastic Agents 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Dacarbazine  INJ  Rs. 519  VIAL
Brand Name Company / Manufacturers Strength Unit Price / VIAL
 DTIC-VHB  Vhb  200MG  VIAL Rs. 519

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Vhb :: DTIC-VHB  Dacarbazine  Anti Neoplastic Agents Anti Neoplastic Agents

Indications for Drugs ::

Metastatic melanoma, Hodgkin’s disease , Soft tissue sarcoma

Drug Dose ::

Adult: IV Metastatic melanoma 2-4.5 mg/kg/day for 10 days, repeat at 4-wkly intervals. Hodgkin’s disease 150 mg/m2/day for 5 days, repeat at 4-wkly intervals. Soft tissue sarcoma 250 mg/m2/day for 5 days, repeat at 3-wkly intervals.

Contraindication ::

Bone marrow suppression; hypersensitivity.

Drug Precautions ::

Hepatic or renal impairment. Pregnancy, lactation.

Drug Side Effects ::

Leucopenia, thrombocytopenia, anorexia, nausea, diarrhoea, vomiting; flu-like syndrome, myalgia, malaise, facial flushing, paraesthesia, skin reactions, rashes; alopoecia, photosensitivity reactions. Potentially Fatal: Myelosuppression; hepatotoxicity, anaphylaxis.

Pregnancy category ::
Pregnancy category


Drug Mode of Action ::  

The exact mechanism of action is still unclear but it appears to form methylcarbonium ions that attack nucleophilic groups by attaching to the 7-position of guanine on DNA. It also cross-links DNA strands leading to inhibition of DNA, RNA and protein synthesis.

Drug Interactions ::

Impairs immune response to vaccines; possible infection after admin of live vaccines. Effect increased by CYP1A2 inhibitors e.g. amiodarone, ciprofloxacin, fluvoxamine, ketoconazole, lomefloxacin, ofloxacin and rofecoxib. Effect decreased by CYP1A2 inducers e.g. aminoglutethimide, carbamazepine, phenobarbital and rifampicin.


Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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