The Brand Name EXELON Has Generic Salt :: Rivastigmine 

EXELON  Is From Company Novartis Priced :: Rs. 3978.00/N.I.

EXELON have Rivastigmine is comes under Sub class Drugs for Neurodegenerative Disorders of  Main Class Nervous System

Main Medicine Class:: Nervous System  Sub Medicine Class :: Drugs for Neurodegenerative Disorders 

Indications for Drugs ::

Severe dementia in Alzheimer’s disease.

Drug Dose ::

Oral Mild to moderately severe dementia in Alzheimer’s disease Adult: Initially, 1.5 mg bid, increased according to response by 1.5 mg bid at intervals of at least 2 wk. If treatment is interrupted for >a few days, restart at 1.5 mg bid and increase dose accordingly, if required. Max: 6 mg bid. Transdermal Indicated for mild, moderate, and severe dementia of the Alzheimer’s type Initial: Apply 4.6 mg q24hr Dose titration: May increase dose to 9.5 mg q24hr after a minimum 4 weeks if well tolerated; after an additional 4 weeks, may further increase to 13.3 mg patch if needed Mild-to-moderate Alzheimer disease: Effective dosage range is 9.5-13.3 mg/24 hr Moderate-to-severe Alzheimer disease: Effective dose is 13.3 mg/24 hr Replace with new patch q24hr

Contraindication ::

Hypersensitivity to other carbamate derivatives. Severe hepatic impairment.

Drug Precautions ::

Patients with sick sinus syndrome or conduction defects, resp diseases. Cholinergic stimulation may increase gastric acid secretion. May exacerbate urinary obstruction and seizures. Pregnancy. Renal impairment, mild to moderate hepatic impairment. Monitor body wt. Asthma or obstructive pulmonary disease. May worsen extrapyramidal symptoms. Lactation.

Drug Side Effects ::

Accidental trauma, fatigue, asthenia, dizziness, headache, somnolence, agitation, insomnia, confusion, depression, nausea, vomiting, diarrhoea, abdominal pain, loss of appetite, dyspepsia, upper respiratory tract infection, urinary tract infection. Rarely, angina pectoris, gastric and duodenal ulcers, GI haemorrhage; bradycardia, seizures, rashes and syncope. Potentially Fatal: Serious GI reactions such as anorexia, vomiting and weight loss.

Pregnancy category ::

2

Drug Mode of Action ::  

Rivastigmine reversibly inhibits hydrolysis of acetylcholine by cholinesterases thus increasing acetylcholine present in the CNS. It is selective for the CNS and is used for the symptomatic treatment of dementia in Alzheimer’s disease and idiopathic Parkinson’s disease.

Drug Interactions ::

Not to be used with other cholinomimetic drugs that might interfere with the activity of anticholinergic medications. May exaggerate the effects of succinylcholine-type muscle relaxants during anaesthesia. Tobacco smoking may increase its clearance.