Article Contents ::
Details About Generic Salt :: Flupentixol
Main Medicine Class:: Nervous System Sub Medicine Class :: Anti Psychotics
| 1D. ANTI-DEPRESSANTS in 1. NERVOUS SYSTEM |
| FLUPENTIXOL |
| D2/5-HT2A ANTAGONIST, D2/D3 AUTORECEPTOR BLOCKER | ANTI-PSYCHOTIC, ANTI-DEPRESSANT |
| also comes under 1E. Anti-Psychotics in 1. Nervous System, |
| PK: A: Rapid M: Hepatic E: urine & feces |
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Indications & Dose: DEPRESSION Mild-to-moderate PO Adult Initially 1mg/day, increased to 2mg after 1wk, then to max 3 mg/day. Doses >2mg should be given in 2 divided doses. If no response with in a wk discontinue therapy Elderly Initially 0.5mg/day, increased to 1mg after 1wk, then to max 2 mg/day. Doses >1mg should be given in 2 divided doses. If no response with in a wk discontinue therapy | PSYCHOSIS PO Adult Initially 3-9mg BID, max18 mg Elderly 1/4th of the initial dose | IM Adult Initially 20mg given as test dose, after 1 wk based upon response administer 20-40mg q2-4 wks. Dose >40mg should be divided between 2 separate injection sites Elderly 1/4th of the initial dose |
| Contra: Hypersensitivity, severe CNS depression, coma, pheochromocytoma, prolactin-dependent tumors
Precautions: Asthma, PUD, bradycardia, arrhythmias, recent coronary occlusion, hyperthyroidism, seizures, parkinsonism, CVD, presence of acute infect/leucopenia, elderly, renal/hepatic impairment, angle-closure glaucoma, history of jaundice, paralytic ileus, myasthenia gravis, DM ADR: Serious: Pseudoparkinsonism, blood disorders, blurred vision, hypotension, tachycardia, hepatitis, seizures, NMS, Others: gynecomastia, anorexia, constipation, nasal congestion, dry eyes, drowsiness, sedation, urinary retention, hyperthermia, allergic reactions, galactorrhea, priapism Diet: Monitor: Vital signs, lipid profile, FBS, HbA1c, EPS, BMI |
